Prevalence and Associated Factors of Significant Bacteriuria by Coagulase Negative Staphylococci at Sekou Toure Regional Referral Hospital in Mwanza, Tanzania
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TextPublisher number: Wurzburg Road 35, BMC Premises, Post Code: 33102 : P. O. Box 1464, Mwanza – Tanzania :Phone: +255 28 298 3384 :Fax: +255 28 298 3386 :Email: vc@bugando.ac.tz :www.bugando.ac.tzLanguage: English Language: Kiswahili Publication details: Mwanza, Tanzania: Catholic University of Health and Allied Sciences [CUHAS – Bugando] : ©2023Description: 53 Pages; Includes ReferencesSubject(s): Summary: Abstract:
Background: Coagulase-negative Staphylococci species (CoNS) seems to be a major cause of most urinary tract infection (UTI) although it’s considered as contaminants. Thus this study has determined the prevalence and associated factors of significant bacteriuria by CoNS at Sekou Toure regional referral hospital in Mwanza Tanzania.
Methods: This cross-sectional analytical hospital-based study was conducted among patients whose urine samples were received in Microbiology laboratory for culture and sensitivity between June and July 2023 at Sekou Toure regional Hospital in Mwanza, Tanzania. Socio-demographic and clinical characteristics were collected from participants using pre-tested structured questionnaire. Conventional bacteriological culture, biochemical identification testing and antibiotics susceptibility testing were performed as per laboratory standard operating procedures (SOPs). Data analysis was done using STATA version 15.
Results: A total of 210 urine samples were received for culture and sensitivity. The overall prevalence of bacterial UTI was 14.9% (31/210) while the prevalence of UTI by CoNS was 2.9% (6/210). S. epidermidis (83.3%; 5/6) and S. saprophyticus (16.7%; 1/6) were the only CoNS isolated causing UTI at this setting. The characteristics of patients with UTI by CoNS was all were outpatients, and majority were females (n=4), aged ≥60 years, had fever (n=4) and used antibiotics (n=5) of which were purchased from pharmacies or drug shops prior to current hospital visits.
Conclusion: This study observed low prevalence of significant bacteriuria by CoNS of which S. epidermidis is predominant among patients attending Sekou Toure regional Referral Hospital in Mwanza. CoNS isolated in the current study were more resistant towards antibiotic agent’s in common clinical practices. We recommend for considerations of CoNS As the causative agent of UTI and surveillance studies to enrich data on the role of CoNS in causing UTI.
Implication of the study: Currently CoNS are considered as urine contaminants, this study has revealed the proportion of CoNS causing UTI, their antimicrobial susceptibility patterns which may guide empiric therapy and factors associated with CoNS which may be used advocating preventive measures.
| Item type | Current library | Collection | Status | Barcode | |
|---|---|---|---|---|---|
| UNDERGRADUATE DISSERTATIONS | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | NFIC | 1 | CUHAS/BM/1001195/T/2 |
Abstract:
Background: Coagulase-negative Staphylococci species (CoNS) seems to be a major cause of most urinary tract infection (UTI) although it’s considered as contaminants. Thus this study has determined the prevalence and associated factors of significant bacteriuria by CoNS at Sekou Toure regional referral hospital in Mwanza Tanzania.
Methods: This cross-sectional analytical hospital-based study was conducted among patients whose urine samples were received in Microbiology laboratory for culture and sensitivity between June and July 2023 at Sekou Toure regional Hospital in Mwanza, Tanzania. Socio-demographic and clinical characteristics were collected from participants using pre-tested structured questionnaire. Conventional bacteriological culture, biochemical identification testing and antibiotics susceptibility testing were performed as per laboratory standard operating procedures (SOPs). Data analysis was done using STATA version 15.
Results: A total of 210 urine samples were received for culture and sensitivity. The overall prevalence of bacterial UTI was 14.9% (31/210) while the prevalence of UTI by CoNS was 2.9% (6/210). S. epidermidis (83.3%; 5/6) and S. saprophyticus (16.7%; 1/6) were the only CoNS isolated causing UTI at this setting. The characteristics of patients with UTI by CoNS was all were outpatients, and majority were females (n=4), aged ≥60 years, had fever (n=4) and used antibiotics (n=5) of which were purchased from pharmacies or drug shops prior to current hospital visits.
Conclusion: This study observed low prevalence of significant bacteriuria by CoNS of which S. epidermidis is predominant among patients attending Sekou Toure regional Referral Hospital in Mwanza. CoNS isolated in the current study were more resistant towards antibiotic agent’s in common clinical practices. We recommend for considerations of CoNS As the causative agent of UTI and surveillance studies to enrich data on the role of CoNS in causing UTI.
Implication of the study: Currently CoNS are considered as urine contaminants, this study has revealed the proportion of CoNS causing UTI, their antimicrobial susceptibility patterns which may guide empiric therapy and factors associated with CoNS which may be used advocating preventive measures.
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