Prevalence and factors assocciated with fungal container packed capsule and tablet at the time of dispensing in accredited drug dispensing outlets in Mwanza Region.
Material type:
TextPublisher number: Phone: +255 28 298 3384 Fax: +255 28 298 3386 Email: vc@bugando.ac.tz Website: www.bugando.ac.tz Language: English Language: Kiswahili Publication details: Mwanza, Tanzania : Catholic University of Health and Allied Sciences [CUHAS - Bugando] : ©17.08.2016Description: ix; 36 Pages; Includes References and AppendicesSubject(s): Summary: Abstract:
Background: Microbial contamination of drugs use for prevention and treatment of human disease at dispensing point, present a serious public health concern among patients. Fungus of different species like Macrosporium, Trichophyton, Epidermophyton, Aspergillus and Candida species are among the microbial reported to contaminate the drugs.
Objective: To determine the prevalence and factors associated with fungal contamination of container packed capsules and tablets at the time of dispensing in accredited drug dispensing outlets (ADDO) shops in Mwanza region.
Methodology: It was a cross sectional study involving 20 ADDO shops selected randomly from Nyamagana and Illemela Districts. From each ADDO shop five different types of medicine represented by (Mebendazole, Vitamin B- Complex, Paracetamol, and folic acid and Indomethacin capsules) were collected randomly from their packs. Samples were transported in the sterile container to microbiology laboratory for microbial analysis following the standard operating procedures. Data was analyzed using the STATA version 11 computer package for data analysis.
Results: The prevalence of contamination was 23.33% (7/30) common contaminated drug was mebendazole tabs which showed contamination by 63%, followed by folic acid tabs 25% and lastly indomethacin caps 12%. The common fungi detected to contaminate the medicine in the selected ADDO shops in Mwanza Region included Aspergillus fumigatus 6(75%), Aspergillus flavus 1 (12.5%) and Candida Tropicalis 1 (12.5%). The risk factors which showed a significant association with drug contamination were: keeping the door open during dispensing and not using the dispensing tools with p value of <0.01 and 0.016 respectively.
Conclusion: There is fungal contamination of the drugs dispensed from ADDO shops in Mwanza region. The most contaminated drug is mebendazole. The main contaminant is Aspergillus spp and is associated with not keeping door open during dispensing and not using dispensing tools. Emphasis should be given on the proper way of dispensing drugs.
| Item type | Current library | Collection | Status | Barcode | |
|---|---|---|---|---|---|
| UNDERGRADUATE DISSERTATIONS | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | NFIC | 1 | UD1698 |
Abstract:
Background: Microbial contamination of drugs use for prevention and treatment of human disease at dispensing point, present a serious public health concern among patients. Fungus of different species like Macrosporium, Trichophyton, Epidermophyton, Aspergillus and Candida species are among the microbial reported to contaminate the drugs.
Objective: To determine the prevalence and factors associated with fungal contamination of container packed capsules and tablets at the time of dispensing in accredited drug dispensing outlets (ADDO) shops in Mwanza region.
Methodology: It was a cross sectional study involving 20 ADDO shops selected randomly from Nyamagana and Illemela Districts. From each ADDO shop five different types of medicine represented by (Mebendazole, Vitamin B- Complex, Paracetamol, and folic acid and Indomethacin capsules) were collected randomly from their packs. Samples were transported in the sterile container to microbiology laboratory for microbial analysis following the standard operating procedures. Data was analyzed using the STATA version 11 computer package for data analysis.
Results: The prevalence of contamination was 23.33% (7/30) common contaminated drug was mebendazole tabs which showed contamination by 63%, followed by folic acid tabs 25% and lastly indomethacin caps 12%. The common fungi detected to contaminate the medicine in the selected ADDO shops in Mwanza Region included Aspergillus fumigatus 6(75%), Aspergillus flavus 1 (12.5%) and Candida Tropicalis 1 (12.5%). The risk factors which showed a significant association with drug contamination were: keeping the door open during dispensing and not using the dispensing tools with p value of <0.01 and 0.016 respectively.
Conclusion: There is fungal contamination of the drugs dispensed from ADDO shops in Mwanza region. The most contaminated drug is mebendazole. The main contaminant is Aspergillus spp and is associated with not keeping door open during dispensing and not using dispensing tools. Emphasis should be given on the proper way of dispensing drugs.
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