Abstract:

Background: Antibiotic resistance happens when germs like bacteria and fungi develop the ability to defeat the drugs designed to kill them. Antimicrobial resistance (AMR), or drug resistance, develops when microbes, including bacteria, fungi, parasites, and viruses, no longer respond to a drug that previously treated them effectively. AMR can lead to the following issues, some infections being harder to control and staying longer inside the body, longer hospital stays, increasing the economic and social costs of infection, a higher risk of disease spreading, greater chance of fatality due to infections.

Objective: The aim of this study was to assessment of rational from irrational drug use to provide awareness of antimicrobial use, prescription, pattern of use, to who and to what infections as in where to use combinational drugs so as to bring about synergistic effect and to determine outcome of the used drug.

Results: 46 participants were enrolled, 65.20% (30/46) were adults, 63% (29/46) were female. 50% (23/46) were confirmed using on antibiotic on the day of survey. The most common prescribed antibiotic was ampiclox 26.1% (6/23) followed by amoxicillin 21.7% (5/23). E. coli was completely resistance to ceftriaxone, amoxicillin-tazobactam. Among all E. coli isolated 22.7% (5/22) all were ESBL producing. DDD per 100 bed-day was 9.81

Conclusion: Our study observed that E. coli is resistant to most common used antibiotics such as ceftriaxone. Continued antibiotic consumption surveillance as well comprehensive multi-centre studies to address the emerging problem of ESBL associated infections.