Seroprevalence and Associated Factors of Rubella IgG Antibodies Among Adolescent Girls in Mwanza City. Tanzania.
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TextPublisher number: Wurzburg Road 35, BMC Premises, Post Code: 33102: P. O. Box 1464, Mwanza – Tanzania: Phone: +255 28 298 3384: Fax: +255 28 298 3386: Email: vc@bugando.ac.tz : www.bugando.ac.tzLanguage: English Language: Kiswahili Publication details: Mwanza, Tanzania: Catholic University of Health and Allied Sciences [CUHAS – Bugando] : ©2016 Description: vii; 29 Pages; Includes ReferencesSubject(s): Summary: Abstract:
Background and objective: Rubella is a viral disease caused by rubella virus and is the major public health concern due its potential in causing poor pregnancy outcome. Infection during early pregnancy is associated with high risk of congenital rubella syndrome (CRS). Prevention of CRS in developing countries requires cost effective strategies. This study is aiming at determining seroprevalence of natural rubella antibodies among adolescent girls, the information that will be useful in devising cost effective control strategy to prevent CRS in Tanzania.
Methods: A cross sectional study was conducted by using achieved sera collected from different secondary schools in Mwanza city. Sociodemographic data and other relevant information were collected by using structured data collection tool. IgG rubella antibodies were detected using enzyme linked immunosorbent assay (ELISA). Data were analyzed by using STATA version 11.
Results: A total of 397 sera from adolescent girls were used, the mean age of these girls was 15.18±1.48 years. Out of 397 adolescent girls; 359 (90.4%) were found to be naturally immune with IgG rubella titers of >10IU/ml. The median rubella IgG antibodies titers were significantly higher among adolescent girls from families with good social economic status (63.96 vs. 47.13 IU/ml, P<0.0001) and those residing in peri-urban areas (63.3 vs. 39.9 IU/ml, P<0.001). Only residing in peri-urban was independent factor found to predict the presence of natural immunity to rubella virus on multivariate logistic regression analysis.
Conclusion and recommendation: About 9.6% of adolescent girls in Mwanza are susceptible to primary rubella virus infection. Policy maker should implement cost effective vaccination strategy to control congenital rubella syndrome in Tanzania by screening and vaccinating susceptible child bearing aged women.
| Item type | Current library | Collection | Status | Barcode | |
|---|---|---|---|---|---|
| UNDERGRADUATE DISSERTATIONS | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | NFIC | 1 | UD0479 |
Abstract:
Background and objective: Rubella is a viral disease caused by rubella virus and is the major public health concern due its potential in causing poor pregnancy outcome. Infection during early pregnancy is associated with high risk of congenital rubella syndrome (CRS). Prevention of CRS in developing countries requires cost effective strategies. This study is aiming at determining seroprevalence of natural rubella antibodies among adolescent girls, the information that will be useful in devising cost effective control strategy to prevent CRS in Tanzania.
Methods: A cross sectional study was conducted by using achieved sera collected from different secondary schools in Mwanza city. Sociodemographic data and other relevant information were collected by using structured data collection tool. IgG rubella antibodies were detected using enzyme linked immunosorbent assay (ELISA). Data were analyzed by using STATA version 11.
Results: A total of 397 sera from adolescent girls were used, the mean age of these girls was 15.18±1.48 years. Out of 397 adolescent girls; 359 (90.4%) were found to be naturally immune with IgG rubella titers of >10IU/ml. The median rubella IgG antibodies titers were significantly higher among adolescent girls from families with good social economic status (63.96 vs. 47.13 IU/ml, P<0.0001) and those residing in peri-urban areas (63.3 vs. 39.9 IU/ml, P<0.001). Only residing in peri-urban was independent factor found to predict the presence of natural immunity to rubella virus on multivariate logistic regression analysis.
Conclusion and recommendation: About 9.6% of adolescent girls in Mwanza are susceptible to primary rubella virus infection. Policy maker should implement cost effective vaccination strategy to control congenital rubella syndrome in Tanzania by screening and vaccinating susceptible child bearing aged women.
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