In Vitro Evaluation of Ethanolic Extract Effectiveness of Stembark of Kigela Africana (Sausage Tree) Against Ciploflaxacin Resistant Neisseria Gonorrhoeae Clinical Isolates in Mwanza, Tanzania.
Material type:
TextPublication details: Mwanza, Tanzania: Catholic University of Health and Allied Sciences [CUHAS – Bugando] ©2017Description: xi; 25 Pages; Includes Refferences and AppendicesSubject(s): Summary: Abstract:
Background: One of the most commonly used plant as herbal remedy in Africa and Tanzania in particular is K.africana which falls in the family of Bignoniaceae, K.africana has been claimed to be used to treat Gonorrhoeae in rural areas of Tanzania, South Africa and Nigeria without scientific proof by rural dwellers.
Due to an emergence of resistant strain of N. gonorrhoeae isolate against Ciprofloxacin and Ceftriaxone which are recommended drug of choice to treat gonorrhoeae. The aim of this study was to determine the antimicrobial activity of K.africana against resistant strain of N. gonorrhoeae and determine the minimum inhibitory concentration.
Methodology: The study was experimental laboratory based study, started from April to July 2017. Stem back of K.africana was collected from Pasiansi Mwanza – Tanzania and grinded aseptically at CUHAS Multipurpose laboratory. Then Extraction using ethanol was done within 72 hours. Extract was transferred to NIMR-Lab for determination of Minimum inhibitory concentration.
Results: Ethanolic extract of K.africana has bactericidal activity against resistant N. gonorrhoeae and MIC was ≥0.025g/ml
Conclusion: This study shows that Ethanolic crude extract of stem back K.africana has bactericidal activity against resistant strain of N. gonorrhoeae. Toxicological studies are recommended so that new pharmaceutical can be produced and overcome the problem of antimicrobial resistance.
| Item type | Current library | Collection | Status | Barcode | |
|---|---|---|---|---|---|
| UNDERGRADUATE DISSERTATIONS | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | NFIC | 1 | UD0254 |
Abstract:
Background: One of the most commonly used plant as herbal remedy in Africa and Tanzania in particular is K.africana which falls in the family of Bignoniaceae, K.africana has been claimed to be used to treat Gonorrhoeae in rural areas of Tanzania, South Africa and Nigeria without scientific proof by rural dwellers.
Due to an emergence of resistant strain of N. gonorrhoeae isolate against Ciprofloxacin and Ceftriaxone which are recommended drug of choice to treat gonorrhoeae. The aim of this study was to determine the antimicrobial activity of K.africana against resistant strain of N. gonorrhoeae and determine the minimum inhibitory concentration.
Methodology: The study was experimental laboratory based study, started from April to July 2017. Stem back of K.africana was collected from Pasiansi Mwanza – Tanzania and grinded aseptically at CUHAS Multipurpose laboratory. Then Extraction using ethanol was done within 72 hours. Extract was transferred to NIMR-Lab for determination of Minimum inhibitory concentration.
Results: Ethanolic extract of K.africana has bactericidal activity against resistant N. gonorrhoeae and MIC was ≥0.025g/ml
Conclusion: This study shows that Ethanolic crude extract of stem back K.africana has bactericidal activity against resistant strain of N. gonorrhoeae. Toxicological studies are recommended so that new pharmaceutical can be produced and overcome the problem of antimicrobial resistance.
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