WEPDD0302: Disability grant terminations and virologic and immunologic response to ARV treatment
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TextPublisher number: Phone: +255 28 298 3384 Fax: +255 28 298 3386 Email: vc@bugando.ac.tz Website: www.bugando.ac.tz Language: English Series: ; Journal of the International AIDS Society Volume 15 Publication details: Mwanza, Tanzania: Journal of the International AIDS Society & Catholic University of Health and Allied Sciences [CUHAS – Bugando] 22 October 2012Description: Pages 18442Online resources: Summary: Abstract:
Background: We evaluated brief combination interventions to simultaneously reduce sexual and injection risks among female sex workers who inject drugs (FSW-IDUs) in Tijuana (TJ) and Ciudad Juarez (CJ) Mexico during 2008-2010, when harm reduction was expanding in TJ, but not CJ.
Methods: FSW-IDUs≥18 years reporting recently sharing injection equipment and unprotected sex with clients participated in a randomized factorial trial comparing four brief, single-session combinations of active motivational-interviewing and didactic interventions focused on negotiating safer-sex in the context of drug use and safer-injection skills. The injection intervention included a video made by FSW-IDUs. Women underwent quarterly interviews and testing for HIV, syphilis, gonorrhea, Chlamydia and Trichomonas. Poisson regression with robust variance estimation and repeated measures ordinal logistic regression via GEE examined effects on HIV/STI incidence and receptive needle sharing frequency, respectively.
Results: Of 599 initially HIV-negative FSW-IDUs (TJ: N=296; CJ: N=303), quarterly retention was≥90%. After 12 months, HIV/STI incidence decreased >50% in the active vs. didactic sex intervention (TJ: AdjRR:0.41, 95%CI: 0.18–0.91, p=0.03; CJ: AdjRR: 0.44, 95%CI: 0.19–0.99, p=0.05)-see tables.
In CJ, women receiving active vs. didactic injection risk interventions decreased receptive needle-sharing by 84% vs. 71%, respectively (p=0.05); in TJ, receptive needle-sharing declined by 95%, but was similar in active vs. didactic groups (p=0.54). TJ women reported significant increases in access to syringes and condoms, but CJ women did not-see figure.
Conclusion: In both cities, a 30-minute intervention promoting safer-sex in the context of drug use significantly reduced HIV/STI incidence with sustained effects at 12 months. Expanding free access to sterile syringes coupled with brief, didactic education on safer injectionwas both necessary and sufficient in achieving dramatic, sustained injection risk reductions in TJ. In the absence of expanding syringe access in CJ, the injection risk intervention still achieved significant, albeit more modest reductions, suggesting that community-level interventions incorporating harm reduction are more powerful than individual-level interventions for reducing injection risks.
| Item type | Current library | Collection | Copy number | Status | Barcode | |
|---|---|---|---|---|---|---|
| RESEARCH ARTICLES | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | NFIC | RA1218 | -1 | RA1218 |
Abstract:
Background: We evaluated brief combination interventions to simultaneously reduce sexual and injection risks among female sex workers who inject drugs (FSW-IDUs) in Tijuana (TJ) and Ciudad Juarez (CJ) Mexico during 2008-2010, when harm reduction was expanding in TJ, but not CJ.
Methods: FSW-IDUs≥18 years reporting recently sharing injection equipment and unprotected sex with clients participated in a randomized factorial trial comparing four brief, single-session combinations of active motivational-interviewing and didactic interventions focused on negotiating safer-sex in the context of drug use and safer-injection skills. The injection intervention included a video made by FSW-IDUs. Women underwent quarterly interviews and testing for HIV, syphilis, gonorrhea, Chlamydia and Trichomonas. Poisson regression with robust variance estimation and repeated measures ordinal logistic regression via GEE examined effects on HIV/STI incidence and receptive needle sharing frequency, respectively.
Results: Of 599 initially HIV-negative FSW-IDUs (TJ: N=296; CJ: N=303), quarterly retention was≥90%. After 12 months, HIV/STI incidence decreased >50% in the active vs. didactic sex intervention (TJ: AdjRR:0.41, 95%CI: 0.18–0.91, p=0.03; CJ: AdjRR: 0.44, 95%CI: 0.19–0.99, p=0.05)-see tables.
In CJ, women receiving active vs. didactic injection risk interventions decreased receptive needle-sharing by 84% vs. 71%, respectively (p=0.05); in TJ, receptive needle-sharing declined by 95%, but was similar in active vs. didactic groups (p=0.54). TJ women reported significant increases in access to syringes and condoms, but CJ women did not-see figure.
Conclusion: In both cities, a 30-minute intervention promoting safer-sex in the context of drug use significantly reduced HIV/STI incidence with sustained effects at 12 months. Expanding free access to sterile syringes coupled with brief, didactic education on safer injectionwas both necessary and sufficient in achieving dramatic, sustained injection risk reductions in TJ. In the absence of expanding syringe access in CJ, the injection risk intervention still achieved significant, albeit more modest reductions, suggesting that community-level interventions incorporating harm reduction are more powerful than individual-level interventions for reducing injection risks.
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