Seroprevalence of Acute Rubella virus Infection and Associated Factors among Women Treated for Abortion Complications in Mwanza City Tanzania.
Material type:
TextPublisher number: Phone: +255 28 298 3384 Fax: +255 28 298 3386 Email: vc@bugando.ac.tz Website: www.bugando.ac.tz Language: English Publication details: Mwanza, Tanzania: Catholic University of Health and Allied Sciences [CUHAS – Bugando] : c2016Description: 41 Pages; Includes References and AppendicesSubject(s): Summary: Abstract:
Background: Acute rubella virus infection in early pregnancy is often associated with poor pregnancy outcomes such as spontaneous abortion, stillbirth and wide range of multiples birth defects known as congenital rubella syndrome (CRS). Despite its importance the role of acute rubella virus infections among women with spontaneous abortion in most of developing countries is not clearly known.
Objectives: This study for the first time in Mwanza aimed at determining seroprevalence and factors associated with acute rubella virus infection among women with spontaneous abortion.
Methods: A cross sectional hospital based study involving 268 women with spontaneous abortion was conducted between November 2015 and April 2016 in four different hospitals in Mwanza city. For each participant about 4mls of bloodsample was collected; sera were extracted and stored at -40 cuntil processing. Acute rubella virus infection was determined by detection of rubella specific IgM antbodies by indirect enzyme linked immunosorbent assay (ELISA). Data analysis was done using STATA version 11
Results: The mean age of enrolled women was 26.3±5.6 years. The prevalence of acute rubella infection was found to be 3.4% (9/268). On multivariate logistic regression analysis; only residing in urban areas (OR: 5.65, 95% CI: 1.13-28.19, p=0.035) was found to predict acute rubella virus infection among women with diagnosis of spontaneous abortion in Mwanza city on multivariate logistic regression analysis.
Conclusion: Considerable proportion of women residing in urban areas of Mwanza city with abortion complications are acutely infected with rubella virus which calls for the need to introduce screening and counselling these women as they attend antenatal clinics.
| Item type | Current library | Collection | Copy number | Status | Barcode | |
|---|---|---|---|---|---|---|
| POSTGRADUATE DISSERTATIONS | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | NFIC | CREC/132023 | 1 | CREC/132023 |
Abstract:
Background: Acute rubella virus infection in early pregnancy is often associated with poor pregnancy outcomes such as spontaneous abortion, stillbirth and wide range of multiples birth defects known as congenital rubella syndrome (CRS). Despite its importance the role of acute rubella virus infections among women with spontaneous abortion in most of developing countries is not clearly known.
Objectives: This study for the first time in Mwanza aimed at determining seroprevalence and factors associated with acute rubella virus infection among women with spontaneous abortion.
Methods: A cross sectional hospital based study involving 268 women with spontaneous abortion was conducted between November 2015 and April 2016 in four different hospitals in Mwanza city. For each participant about 4mls of bloodsample was collected; sera were extracted and stored at -40 cuntil processing. Acute rubella virus infection was determined by detection of rubella specific IgM antbodies by indirect enzyme linked immunosorbent assay (ELISA). Data analysis was done using STATA version 11
Results: The mean age of enrolled women was 26.3±5.6 years. The prevalence of acute rubella infection was found to be 3.4% (9/268). On multivariate logistic regression analysis; only residing in urban areas (OR: 5.65, 95% CI: 1.13-28.19, p=0.035) was found to predict acute rubella virus infection among women with diagnosis of spontaneous abortion in Mwanza city on multivariate logistic regression analysis.
Conclusion: Considerable proportion of women residing in urban areas of Mwanza city with abortion complications are acutely infected with rubella virus which calls for the need to introduce screening and counselling these women as they attend antenatal clinics.
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