Prevalence and predictors of Immunological treatment failure among HIV infected adults on the first line antiretroviral therapy in Mbeya Region, Tanzania
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TextPublisher number: Wurzburg Road 35, BMC Premises, Post Code: 33102: P. O Box 1464, Mwanza – Tanzania: Phone: +255 28 298 3384: Fax: +255 28 298 3386: Email: vc@bugando.ac.tz :www.bugando.ac.tzLanguage: English Publication details: Mwanza, Tanzania: Catholic University of Health and Allied Sciences CUHAS - Bugando : ©2016Description: xvi; 60 Pages; Includes References and AppendicesSubject(s): Summary: Abstract:
Background: Antiretroviral therapy (ART) has shown to delay progression to AIDS, resulting in greater and more sustained virologic and immunologic response and improve survival. First-line ART treatment failure occurs when drugs being administered for the treatment of HIV are no longer able to kill the virus. Immunological failure is a common challenge among HIV-infected patients of first-line ART in resource-limited settings. However, the magnitude and predictors associated with it are not yet understood in Mbeya region. Therefore this study highlighted the magnitude of immunological failure and its predictors among adult HIV-infected patients (with age ≥15yrs) on ART in Mbeya Regional and Mbalizi Council Designated Hospitals, Mbeya Region, Tanzania.
Methods: This was a cross sectional study which analyzed data of 2565 HIV-infected patients (≥15yrs) on ART from January 1st 2010 to June 30th 2016 enrolled at Mbeya Regional and Mbalizi Council Designated Hospitals. Data were obtained from the CTC2 electronic database, patients’ CTC2 cards; patients’ ART registers laboratory result forms and clinical notes in the patient files. Data were quantitatively analyzed to determine the factors influencing the immunological treatment failure.
Results: A total of 2565 patients’ records were reviewed and followed backwards for median duration of 24.5 [13.6-43.6] months. About 64.4% were female and the median age was 41 years (IQR: 35-48). The median baseline CD4 count was 194cells/µl (OR:7.2[5.7-9.2]), age (OR:1.01[1.002 – 1.02]), being patient from District Council designated hospital (OR:1.2[1.1 – 1.5]), hemoglobin count <8g/dL, (OR: 1.4[1.1-1.8]), longer duration from HIV diagnosis to ART initiation (OR:1.9[1.2-3.0]), AZT –based regimen (1.3[1.1-16]) and immunological treatment failure.
Conclusions: Immunological failure was significantly predicted by older age (>40yrs), baseline CD4 of ≥350cell/µl, being patient from District Council designated hospital, severe anemia, longer duration from HIV diagnosis from HIV diagnosis to ART initiation and AZT-based regimen.
| Item type | Current library | Collection | Status | Barcode | |
|---|---|---|---|---|---|
| POSTGRADUATE DISSERTATIONS | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | NFIC | 1 | PD0179 |
Abstract:
Background: Antiretroviral therapy (ART) has shown to delay progression to AIDS, resulting in greater and more sustained virologic and immunologic response and improve survival. First-line ART treatment failure occurs when drugs being administered for the treatment of HIV are no longer able to kill the virus. Immunological failure is a common challenge among HIV-infected patients of first-line ART in resource-limited settings. However, the magnitude and predictors associated with it are not yet understood in Mbeya region. Therefore this study highlighted the magnitude of immunological failure and its predictors among adult HIV-infected patients (with age ≥15yrs) on ART in Mbeya Regional and Mbalizi Council Designated Hospitals, Mbeya Region, Tanzania.
Methods: This was a cross sectional study which analyzed data of 2565 HIV-infected patients (≥15yrs) on ART from January 1st 2010 to June 30th 2016 enrolled at Mbeya Regional and Mbalizi Council Designated Hospitals. Data were obtained from the CTC2 electronic database, patients’ CTC2 cards; patients’ ART registers laboratory result forms and clinical notes in the patient files. Data were quantitatively analyzed to determine the factors influencing the immunological treatment failure.
Results: A total of 2565 patients’ records were reviewed and followed backwards for median duration of 24.5 [13.6-43.6] months. About 64.4% were female and the median age was 41 years (IQR: 35-48). The median baseline CD4 count was 194cells/µl (OR:7.2[5.7-9.2]), age (OR:1.01[1.002 – 1.02]), being patient from District Council designated hospital (OR:1.2[1.1 – 1.5]), hemoglobin count <8g/dL, (OR: 1.4[1.1-1.8]), longer duration from HIV diagnosis to ART initiation (OR:1.9[1.2-3.0]), AZT –based regimen (1.3[1.1-16]) and immunological treatment failure.
Conclusions: Immunological failure was significantly predicted by older age (>40yrs), baseline CD4 of ≥350cell/µl, being patient from District Council designated hospital, severe anemia, longer duration from HIV diagnosis from HIV diagnosis to ART initiation and AZT-based regimen.
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