ABSTRACT:

Background: Mineral bone disorder is a significant problem among patients with chronic kidney disease. This has been extensively studied in developed countries and shown to be associated with increased morbidity and mortality in this subgroup of patients. The literature on the magnitude of the problem is still scarce in our setting.

Objective: To determine prevalence and factors associated with mineral bone disorder among patients with CKD at Bugando Medical centre and to compare this prevalence with patients who do not have CKD.

Methods: This was a cross sectional study done between November 2016 to March 2017 among patients with and without chronic kidney disease. Social-demographic factors, clinical features and laboratory results regarding bone minerals and renal functions were collected in a special tool and analyzed using STATA 13.

Results: A total of 191(122 with CKD) were enrolled in the study. MBD was found in 139 (72.8%) of the study participants. The prevalence was significantly higher among patients with CKD as compared to controls (82.8% vs.55.1 %, p value <0.0001). The odds of having mineral bone disease among patients with CKD was strongly associated with eGFR< 60 kg/min/m2 (OR 3.39:95% CI [1.16 - 9.97] p-value 0.03).

Conclusion: The mineral bone disorder is prevalent among adult patients with CKD and it is significantly associated with eGFR< 60mls/min/1.73m2. Given the morbidity associated with mineral bone disorder and the difficulty of reversing its effects once it occurs, efforts to prevent CKD could potentially reduce the magnitude of this problem in this subgroup of patients.