Includes bibliographical references and index.

I. In vitro models / James D. Lindsey -- 1. Culture of retinal neurons -- II. In vivo models of optic nerve damage -- 2. Crush injury of the optic nerve / Michal Schwartz and Eti Yoles -- 3. Intraocular pressure elevation: vein cauterization / Sansar C. Sharma -- 4. Intraocular pressure elevation: injecting hypertonic saline into episcleral veins / John C. Morrison, Elaine C. Johnson, Lijun Jia, and William O. Cepurna -- 5. Intraocular pressure elevation: laser photocoagulation of the trebecular meshwork / B'Ann T. Gabelt, James N. Ver Hoeve, and Paul L. Kaufman -- III. In vivo models of retinal damage -- 6. Light-induced retinal degeneration / Daniel T. Organisciak, R. M. Darrow, and L.S. Barsalou -- 7. Retinal degeneration / Ward M. Peterson -- 8. Retinal ischemia / Manuel Vidal-Sanz et al -- IV. Neuroprotective strategies -- 9. Drug delivery / Robert W. Nickells and Cassandra L. Schlamp -- 10. Recombinant viral vectors / Przemyslaw Sapieha and Adriana Di Polo -- V. Analysis of neuronal survival and function -- 11. Quantification of retinal cells / Christine A. Curcio and Kenneth R. Sloan -- 12. Ex vivo and whole-mount retinal preparations / Arthur J. Weber -- 13. Detection of single-cell apoptosis / William G. Tatton, Ruth M.E. Chalmers-Redman, and Nadine A. Tatton -- 14. Imaging of retinal ganglion cells / Joshua P. Vrabec and Leonard A. Levin -- 15. Evaluation of retinal function: electroretinography / Marc Hébert and Pierre Lachapelle -- VI. Clinical trials -- 16. Evaluation of visual outcome / Pamela A. Sample -- 17. Clinical trials in neuroprotection / Scott M. Whitcup -- 18. Regulatory issues in clinical trials / Anthony C. Arnold -- Index.