Control and Prediction of Solid-State of Pharmaceuticals (Record no. 7283)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03523nam a22002657a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20240305192500.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220616b |||||||| |||| 00| 0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 3319275550 |
| International Standard Book Number | 9783319275550 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | dlc |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 541 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Rajni Miglani Bhardwaj |
| 9 (RLIN) | 39185 |
| 245 ## - TITLE STATEMENT | |
| Title | Control and Prediction of Solid-State of Pharmaceuticals |
| Remainder of title | Experimental and Computational Approaches |
| Statement of responsibility, etc. | Springer Theses |
| 250 ## - EDITION STATEMENT | |
| Edition statement | illustrated |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Lilly Corporate Center Eli Lilly and Company Indianapolis, IN USA |
| Name of publisher, distributor, etc. | Springer |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 238 pages |
| 505 ## - FORMATTED CONTENTS NOTE | |
| Formatted contents note | Contents:<br/><br/>1 Introduction<br/><br/>2 Aims and Objectives<br/><br/>3 Materials and Methods<br/><br/>4 Development and Validation of HighThroughput Crystallisation and Analysis HTCAA Methodology for Physical Form Screening<br/><br/>5 Predicting Crystallisability of Organic Molecules Using Statistical Modelling Techniques<br/><br/>6 Exploring the Crystal Structure Landscape of Olanzapine<br/><br/>7 Exploring the Physical Form Landscape of Clozapine Amoxapine and Loxapine<br/><br/>8 Conclusions and Further Work<br/><br/>Appendix<br/><br/> |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | This thesis investigates a range of experimental and computational approaches for the discovery of solid forms. Furthermore, we gain, as readers, a better understanding of the key factors underpinning solid-structure and diversity. A major part of this thesis highlights experimental work carried out on two structurally very similar compounds. Another important section involves looking at the influence of small changes in structure and substituents on solid-structure and diversity using computational tools including crystal structure prediction, PIXEL calculations, Xpac, Mercury and statistical modeling tools. In addition, the author presents a fast validated method for solid-state form screening using Raman microscopy on multi-well plates to explore the experimental crystallization space. This thesis illustrates an inexpensive, practical and accurate way to predict the crystallizability of organic compounds based on molecular structure alone, and additionally highlights the molecular factors that inhibit or promote crystallization. |
| Expansion of summary note | Common terms and phrases: acetic acid amorphous amoxapine analysis anhydrous approaches arrangement atoms AXPN blue Carbon tetrachloride carried Chem chemical classification clozapine collected colour compounds computational conformation contribution Cryst crystal energy landscape crystal structures crystallisation CZPN descriptors Dihydrate diversity drug effect et al ethanol experimental experiments Figure Florence form II further green Growth H-bonds hydrogen bonding identified interactions intermolecular interactions involving known loxapine LXPN material method mixture molecular molecular pairs molecules monohydrate novel nucleation observed obtained olanzapine organic outcome OZPN packing pharmaceutical phase physical form screening plate plot polymorphs potential prediction present Price properties provides Raman spectra Raman spectroscopy Random range region reported represents respectively salts sample Sect selection showed shown similar solid form solid-state solution Solvate hydrate solvent space space group Stack statistical Table techniques temperature various XRPD |
| 600 ## - SUBJECT ADDED ENTRY--PERSONAL NAME | |
| General subdivision | Technology & Engineering / Chemical & Biochemical |
| 9 (RLIN) | 28700 |
| General subdivision | Science / Chemistry / Physical & Theoretical |
| 9 (RLIN) | 33677 |
| General subdivision | Medical / Pharmacy |
| 9 (RLIN) | 27229 |
| General subdivision | Science › Chemistry › Physical & Theoretical |
| 9 (RLIN) | 39186 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | ddc |
| Koha item type | E-BOOKS |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | 06/16/2022 | 541 | EBS11759 | 06/16/2022 | 06/16/2022 | E-BOOKS |