Diabetes Mellitus (Record no. 29195)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02411nam a22003017a 4500 |
| 001 - CONTROL NUMBER | |
| control field | 20241017094432.0 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OCoLC |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20241017094843.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 241017b |||||||| |||| 00| 0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 978-981-13-3540-2 (eBook) |
| International Standard Book Number | 978-981-13-3539-6 |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 0065-2598 |
| International Standard Serial Number | 2214-8019 (electronic) |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | ddc |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | English |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616.462 NAK |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Fuller form of name | Yusaku Nakabeppu |
| 245 ## - TITLE STATEMENT | |
| Title | Diabetes Mellitus |
| Remainder of title | A risk factor for Alzheimer’s Disease |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience Medical Institute of Bioregulation, Kyushu University Fukuoka, Japan | |
| Name of publisher, distributor, etc. | Springer Nature Singapore Pte Ltd | |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 247 Pages |
| Extent | Includes References |
| 490 ## - SERIES STATEMENT | |
| Series statement | Advances in Experimental Medicine and Biology |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | <br/>This book describes the precise mechanisms by which insulin resistance and diabetes mellitus (DM) act as risk factors for Alzheimer’s disease (AD). It opens by discussing the de novo synthesis of insulin in the brain and its functional significance with regard to glucose metabolism and maintenance of neuronal function in the brain. The epidemiological evidence that DM is a risk factor for the development of dementia, including AD as well as vascular dementia, is then examined. Subsequent chapters explore in depth the mechanisms involved in this relationship, including abnormal protein processing, dysregulated glucose metabolism, impaired insulin signaling, and mitochondrial dysfunction. The molecular interactions between diabetes and AD are fully discussed, highlighting the pathological molecular mechanisms induced by diabetes that promote and accelerate AD pathology. Finally, diagnostic biomarkers and potential therapeutic approaches for AD are considered on the basis of the presented evidence. In providing answers to the critical questions of whether and why DM is a risk factor for AD, this book will hold appeal for a wide interdisciplinary audience. |
| 600 ## - SUBJECT ADDED ENTRY--PERSONAL NAME | |
| General subdivision | Diseases, Medical / Endocrinology & Metabolism, Medical / General, Medical / Neurology, Medical / Neuroscience, Neurology, Neurosciences, Science / Life Sciences / Neuroscience, Alzheimer's disease -- Risk factors, Diabetes. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Fuller form of name | Toshiharu Ninomiya |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1007/978-981-13-3540-2 ">https://doi.org/10.1007/978-981-13-3540-2 </a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | ddc |
| Koha item type | E-BOOKS |
| Suppress in OPAC | |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Date acquired | Total checkouts | Full call number | Barcode | Date last seen | Uniform resource identifier | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | 10/17/2024 | 616.462 NAK | 20241017094432.0 | 10/17/2024 | https://doi.org/10.1007/978-981-13-3540-2 | 10/17/2024 | E-BOOKS |