Clinical-Pathological Features and Overexpression of Her-2 Receptors in Patients with Prostate Cancer at Bugando Medical Center, Mwanza, Tanzania. (Record no. 29096)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 02854nam a22003257a 4500 |
| 001 - CONTROL NUMBER | |
| control field | 20241009130647.0 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | 20241009130647.0 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20241009131055.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 241009b |||||||| |||| 00| 0 eng d |
| 028 ## - PUBLISHER OR DISTRIBUTOR NUMBER | |
| Source | Wurzburg Road 35, Premises, Post Code: 33102 | |
| Source | P. O. Box 1464 Mwanza, Tanzania | |
| Source | Phone: (255) 28-298-3384 | |
| Source | Fax: (255) 28-298-3386 | |
| Source | Email: vc@bugando.ac.tz | |
| Source | Website: www.bugando.ac.tz |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | ddc |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | English |
| Language code of text/sound track or separate title | Kiswahili |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Relator term | CUHAS/MMED/6000467/T/21 |
| Fuller form of name | Maria Beda |
| 245 ## - TITLE STATEMENT | |
| Title | Clinical-Pathological Features and Overexpression of Her-2 Receptors in Patients with Prostate Cancer at Bugando Medical Center, Mwanza, Tanzania. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mwanza, Tanzania | |
| Name of publisher, distributor, etc. | Catholic University of Health and Allied Sciences [CUHAS-Bugando] | |
| Date of publication, distribution, etc. | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 91 Pages |
| Extent | Includes References |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | <br/>Abstract:<br/><br/>Background: Overexpression of the human epidermal growth factor receptor 2 (HER-2) has been associated with aggressive progression and high mortality in patients with prostate cancer. HER-2-targeted therapy has been suggested to be of therapeutic importance in prostate cancer patients who do not respond to a commonly used treatment modality. Therefore, this study aims to determine HER-2 overexpression in prostate cancer and its association with clinical-pathological.<br/><br/>Methodology: This was a laboratory-based, cross-sectional study involving 97 patients with prostate adenocarcinoma. Tissue blocks were retrieved for immunohistochemistry (IHC) staining of HER-2 on which tissue microarray was don. Monoclonal antibodies to HER-2(ref no: A0485, lot no: 4140026(DAKO) used. The IHC staining scores of +2 and +3 were considered positive.<br/><br/>Results: A total number of 97 cases were included in this study, the median PSA level was 102ng/ml (range, 60 – 400ng/ml). HER-2 membrane overexpression was observed in 50 of 97 (51.55%) the cases, while 47cases (48.45%) were negative. There was a significant association of HER-2 overexpression with PSA level (P value 0.006) and Gleason grade (P value 0.012).<br/><br/>Conclusion: Prostate cancer in our setting showed a high level of HER-2 overexpression. These findings recommend further studies including clinical trials to be done for all patients with a high Gleason score and elevated PSA for HER-2 overexpression so that they can benefit from targeted therapy (trastuzumab).<br/><br/> |
| 600 ## - SUBJECT ADDED ENTRY--PERSONAL NAME | |
| General subdivision | Pathology |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Fuller form of name | Oscar Ottoman Muhini |
| Fuller form of name | Peter Fabian Rambau |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Public note | A dissertation submitted in partial fulfillment of the requirements of the award of Master of Medicine in Anatomical Pathology of Catholic University of Health and Allied Sciences (CUHAS). |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | ddc |
| Koha item type | POSTGRADUATE DISSERTATIONS |
| Suppress in OPAC | |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Date acquired | Total checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | 10/09/2024 | 20241009130647.0 | 10/09/2024 | 10/09/2024 | POSTGRADUATE DISSERTATIONS |