Comparative analysis of sterility and active pharmaceutical ingredient content in imported and locally manufactured prednisolone and chloramphenicol eye drops. (Record no. 28829)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02958nam a22003017a 4500 |
| 001 - CONTROL NUMBER | |
| control field | 20240923092349.0 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | 20240923092349.0 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20241022131533.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 240923b |||||||| |||| 00| 0 eng d |
| 028 ## - PUBLISHER OR DISTRIBUTOR NUMBER | |
| Source | Wurzburg Road 35, Premises, Post Code: 33102 | |
| Source | P. O. Box 1464 Mwanza, Tanzania | |
| Source | Phone: (255) 28-298-3384 | |
| Source | Fax: (255) 28-298-3386 | |
| Source | Email: vc@bugando.ac.tz | |
| Source | Website: www.bugando.ac.tz |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | ddc |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | English |
| Language code of text/sound track or separate title | Kiswahili |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Relator term | CUHAS/BP/3001298/T/20 |
| Fuller form of name | Aniceth Hansfrid Kabagambe |
| 245 ## - TITLE STATEMENT | |
| Title | Comparative analysis of sterility and active pharmaceutical ingredient content in imported and locally manufactured prednisolone and chloramphenicol eye drops. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mwanza, Tanzania | |
| Name of publisher, distributor, etc. | Catholic University of Health and Allied Sciences [CUHAS-Bugando] | |
| Date of publication, distribution, etc. | 2024. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | Includes References |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Abstract:<br/><br/><br/>"Introduction: The quality of finished pharmaceutical products, including ophthalmic preparations, depends on good manufacturing practices, adherence to the established standard operating procedures, and availability of clean room requirements in manufacturing facilities. Inability to comply with these requirements leads to poor quality of the products. This study aimed to determine the sterility level and API content of imported and locally manufactured prednisolone and chloramphenicol eye drops<br/><br/>Methods: This laboratory-based analytical study was conducted at Tanzania Medicine and Medical Devices Authority (TMDA) laboratory, Mwanza, Tanzania. Imported chloramphenicol and prednisolone eye drop samples were obtained from community pharmacies in Nyamagana, Mwanza whereas, the locally manufactured samples of the same were obtained from Kilimanjaro Christian Medical Centre. Prednisolone and Chloramphenicol eye drop samples were analysed by membrane filtration and HPLC methods for sterility and API content, respectively.<br/><br/>Results and Discussion: All prednisolone eye drop samples were found to be sterile whereas, two samples out of four, for chloramphenicol eye drops, failed the assay test, according to pharmacopoeia standards. Locally manufactured chloramphenicol eye drops passed the assay test which suggests that local manufacturers are capable of producing high-quality and reliable pharmaceutical products.<br/><br/>Conclusion: All prednisolone eye drop samples were found to be sterile whereas only two chloramphenicol eye drop samples passed the assay test. The TMDA should withdraw from the market, chloramphenicol eye drops which failed the assay test."<br/> |
| 600 ## - SUBJECT ADDED ENTRY--PERSONAL NAME | |
| General subdivision | Medicinal Chemistry and Pharmacognosy |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Fuller form of name | Tanga Yango Mafuru |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Public note | Research Report Submitted in Partial Fulfilment for The Award of Bachelor of Pharmacy Degree of The Catholic University of Health and Allied Sciences. |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | ddc |
| Koha item type | UNDERGRADUATE DISSERTATIONS |
| Suppress in OPAC | |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Date acquired | Total checkouts | Barcode | Date last seen | Price effective from | Koha item type |
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| MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | 09/23/2024 | 20240923092349.0 | 09/23/2024 | 09/23/2024 | UNDERGRADUATE DISSERTATIONS |