Challenges in Diagnosing and Treating Acutely Febrile Children with Suspected Malaria at Health Care Facilities in the Lake Mwanza Region of Tanzania (Record no. 28053)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03185nam a22004697a 4500 |
| 001 - CONTROL NUMBER | |
| control field | 20240611093631.0 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | 20240611093631.0 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20240611094927.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 240611b |||||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | ddc |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | English |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Fuller form of name | Philip Koliopoulos |
| 245 ## - TITLE STATEMENT | |
| Title | Challenges in Diagnosing and Treating Acutely Febrile Children with Suspected Malaria at Health Care Facilities in the Lake Mwanza Region of Tanzania |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mwanza, Tanzania : |
| Name of publisher, distributor, etc. | Catholic University of Health and Allied Sciences [CUHAS-Bugando] : |
| Date of publication, distribution, etc. | 2023 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | Pages 01-07 |
| Extent | Includes References |
| 490 ## - SERIES STATEMENT | |
| Volume/sequential designation | Am J Trop Med Hyg. 2024 Feb; 110(2): 202–208. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Abstract:<br/><br/>Acute febrile diseases transmitted by mosquitos are a diagnostic challenge for pediatricians working in sub-Saharan Africa. Misclassification due to the lack of rapid, reliable diagnostic tests leads to the overuse of antibiotics and antimalarials. Children presenting with acute fever and suspected of having malaria were examined at health care facilities in the Mwanza Region of Tanzania. The sensitivity and specificity of blood smear microscopy and malaria rapid diagnostic tests that targeted histidine-rich protein 2 and Plasmodium lactate dehydrogenase were compared with a multiplex reverse transcriptase-polymerase chain reaction (PCR)–ELISA. Six hundred ninety-eight children presented with acute fever and met the criteria for inclusion; 23% received antibiotics and 23% received antimalarials prior to admission. Subsequently, 20% were confirmed by PCR to have Plasmodium falciparum infection. Blood smear microscopy exhibited 33% sensitivity and 93% specificity. The malaria rapid test provided 87% sensitivity and 98% specificity in detecting acute malaria infections. Only 7% of malaria-negative children received antimalarials at Sengerema Designated District Hospital when treatment was guided by the results of rapid testing. In contrast, 75% of malaria-negative patients were treated with antimalarial drugs at health facilities that used blood smears as the standard diagnostic test. Misclassification and premedication of nonmalarial, febrile illnesses contribute to the emergence of antimalarial and antimicrobial resistance. The incorporation of malaria rapid diagnostic tests into the clinical routine translated into improved treatment and a significant reduction in antimalarial drug prescriptions. |
| 600 ## - SUBJECT ADDED ENTRY--PERSONAL NAME | |
| General subdivision | Malaria |
| General subdivision | Children |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Fuller form of name | Neema Kayange |
| Fuller form of name | Christian Jensen |
| Fuller form of name | Britta Gröndahl |
| Fuller form of name | Jana Eichmann |
| Fuller form of name | Tim Daniel |
| Fuller form of name | Florian Huth |
| Fuller form of name | Till Eckert |
| Fuller form of name | Nele Klamm |
| Fuller form of name | Marlene Follmann |
| Fuller form of name | Grey Carolina Medina-Montaño |
| Fuller form of name | Adolfine Hokororo |
| Fuller form of name | Leah Pretsch |
| Fuller form of name | Julia Klüber |
| Fuller form of name | Christian Schmidt |
| Fuller form of name | Antke Züchner |
| Fuller form of name | Marylyn M. Addo |
| Fuller form of name | Bernard Okamo |
| Fuller form of name | Stephen E. Mshana |
| Fuller form of name | Stephan Gehring |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="10.4269/ajtmh.23-0254">10.4269/ajtmh.23-0254</a> |
| Link text | 10.4269/ajtmh.23-0254 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | ddc |
| Koha item type | RESEARCH ARTICLES |
| Suppress in OPAC | |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Date acquired | Total checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | 06/11/2024 | 20240611093631.0 | 06/11/2024 | 06/11/2024 | RESEARCH ARTICLES |