Treatment delays in children and young adults with lymphoma (Record no. 28024)
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| 000 -LEADER | |
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| fixed length control field | 04837nam a22004097a 4500 |
| 001 - CONTROL NUMBER | |
| control field | 20240610135137.0 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | 20240610135137.0 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20240610141102.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 240610b |||||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | ddc |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | English |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Fuller form of name | William Frank Mawalla |
| 245 ## - TITLE STATEMENT | |
| Title | Treatment delays in children and young adults with lymphoma |
| Remainder of title | a report from an East Africa lymphoma cohort study |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mwanza, Tanzania : |
| Name of publisher, distributor, etc. | Catholic University of Health and Allied Sciences [CUHAS-Bugando] : |
| Date of publication, distribution, etc. | 2023 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | Pages 01-04 |
| Extent | Includes References |
| 490 ## - SERIES STATEMENT | |
| Volume/sequential designation | Blood Advances First Edition 12 May 2023; final version published online 25 August 2023 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Lymphomas are a diverse group of hematopoietic neoplasms resulting from the malignant transformation of lymphoid cells and their precursors.1 If diagnosed early and precisely, most lymphomas in children and young adults have excellent cure rates of up to 90% using affordable treatments from the essential medicine list by the World Health Organization.2-6 In contrast, prolonged time-to-diagnosis and treatment usually results in poor treatment outcomes, especially in aggressive lymphoma types.7 In sub-Saharan Africa (SSA), cited causes of delay in diagnosis and treatment are low socioeconomic status, poor health-seeking behavior and access to health care, an inefficient health care referral system, a shortage of trained experts, and limited diagnostic capability.8,9 Studies analyzing delays in the diagnosis and treatment of lymphoma in SSA are limited. An objective assessment of the time to definitive care and associated factors is crucial in identifying intervention points along the pathway to care for patients with lymphoma in resource-restricted regions. <br/><br/>Here, we present the results of a prospective multicenter study involving 2 East African countries that evaluates both patient and health care–related delays among children and young adults diagnosed with lymphoma. The study was conducted at 3 tertiary cancer hospitals in Tanzania and 1 cancer center, St Mary’s Hospital-Lacor Hospital, in Northern Uganda. The centers in Tanzania included Muhimbili National Hospital in Dar es Salaam, Kilimanjaro Christian Medical Centre in Kilimanjaro, and Bugando Medical Centre in the Mwanza region, north of Tanzania. Ethical approval was granted by the Oxford Tropical Research Ethics Committee, the National Institute of Medical Research in Tanzania, the Uganda National Council of Science and Technology, and the Lacor Hospital Institutional Research Ethics Committee in Uganda. The AI-REAL study enrolled children and young adults (aged 3-30 years) presenting with suspected lymphoma. Here, we focus on the subset of patients with a biopsy-confirmed lymphoma diagnosis. For all enrolled patients, demographic and baseline clinical data, including the date they first experienced symptoms, the date they first visited a local health care center, and the date the local health care center referred them to the tertiary cancer center, were recorded. Upon arrival at the tertiary cancer treatment centers, the dates and times of tissue sampling, arrival of tissue in the pathology laboratory for processing and pathology reports (with and without immunohistochemistry), and start of definitive cancer treatment were recorded. The primary outcome was the median total treatment delay and its individual components. Total treatment delay was defined as the time from the onset of symptoms to the start of definitive cancer treatment. The total treatment delay included the time-to-first health care contact (from the onset of symptoms) to contact with the first health care facility, excluding the visit to traditional healers, time-to-referral (from the first health care facility contact to arrival at a cancer treatment center), and time-to-treatment after arrival at a cancer center (time from arriving at a cancer treatment center to receiving definitive cancer treatment). Time-to-diagnosis was defined as the time from arrival at a cancer center to receiving a tissue diagnosis report, either a morphology report alone or a morphology with immunohistochemistry (IHC) report.<br/> |
| 600 ## - SUBJECT ADDED ENTRY--PERSONAL NAME | |
| General subdivision | Lymphoma |
| General subdivision | Lymphoma cohort |
| General subdivision | Children |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Fuller form of name | Liz Morrell |
| Fuller form of name | Lulu Chirande |
| Fuller form of name | Caroline Achola |
| Fuller form of name | Hadija Mwamtemi |
| Fuller form of name | Godlove Sandi |
| Fuller form of name | Salama Mahawi |
| Fuller form of name | Atukuzwe Kahakwa |
| Fuller form of name | Paul Ntemi |
| Fuller form of name | Nabalende Hadija |
| Fuller form of name | Elifuraha Mkwizu |
| Fuller form of name | Clara Chamba |
| Fuller form of name | Dimitris Vavoulis |
| Fuller form of name | Anna Schuh |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1182/bloodadvances.2022009398">https://doi.org/10.1182/bloodadvances.2022009398</a> |
| Link text | . https://doi.org/10.1182/bloodadvances.2022009398 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | ddc |
| Koha item type | RESEARCH ARTICLES |
| Suppress in OPAC | |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Date acquired | Total checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | 06/10/2024 | 20240610135137.0 | 06/10/2024 | 06/10/2024 | RESEARCH ARTICLES |