Molecular Characterizations of the Coagulase-Negative Staphylococci Species Causing Urinary Tract Infection in Tanzania (Record no. 27988)
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| fixed length control field | 03213nam a22004577a 4500 |
| 001 - CONTROL NUMBER | |
| control field | 20240607192123.0 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | 20240607192123.0 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20240607193150.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
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| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | EISSN 2076-0817 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | ddc |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | English |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Fuller form of name | Shukrani Phillip |
| 245 ## - TITLE STATEMENT | |
| Title | Molecular Characterizations of the Coagulase-Negative Staphylococci Species Causing Urinary Tract Infection in Tanzania |
| Remainder of title | A Laboratory-Based Cross-Sectional Study |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mwanza, Tanzania : |
| Name of publisher, distributor, etc. | Catholic University of Health and Allied Sciences [CUHAS-Bugando] : |
| Date of publication, distribution, etc. | 2023 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | Pages 01-12 |
| Extent | Includes References |
| 490 ## - SERIES STATEMENT | |
| Volume/sequential designation | Pathogens 2023, 12, 180. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Abstract :<br/><br/>Background: There is a growing body of evidence on the potential involvement of coagulase-negative Staphylococci (CoNS) in causing urinary tract infections (UTIs). The aim of this study was to delineate virulence potential, antimicrobial resistance genes, and sequence types of CoNS isolated from patients with UTI symptoms and pyuria in Tanzania. <br/><br/>Methods: CoNS from patients with UTI symptoms and more than 125 leucocytes/μL were retrieved, subcultured, and whole-genome sequenced. <br/><br/>Results: Out of 65 CoNS isolates, 8 species of CoNS were identified; Staphylococcus haemolyticus, n = 27 (41.5%), and Staphylococcus epidermidis, n = 24 (36.9%), were predominant. The majority of S. haemolyticus were sequence type (ST) 30, with 8 new ST138-145 reported, while the majority of S. epidermidis were typed as ST490 with 7 new ST1184-1190 reported. Sixty isolates (92.3%) had either one or multiple antimicrobial resistance genes. The most frequently detected resistance genes were 53 (21%) dfrG, 32 (12.9%) blaZ, and 26 (10.5%) mecA genes conferring resistance to trimethoprim, penicillin, and methicillin, respectively. Out of 65 isolates, 59 (90.8%) had virulence genes associated with UTI, with a predominance of the icaC 47 (46.5%) and icaA 14 (13.9%) genes. <br/><br/>Conclusion: S. haemolyticus and S. epidermidis harboring icaC, dfrG, blaZ, and mecA genes were the predominant CoNS causing UTI in Tanzania. Laboratories should carefully interpret the significant bacteriuria due to CoNS in relation to UTI symptoms and pyuria before labeling them as contaminants. Follow-up studies to document the outcome of the treated patients is needed to add more evidence that CoNS are UTI pathogens. |
| 600 ## - SUBJECT ADDED ENTRY--PERSONAL NAME | |
| General subdivision | S. epidermidis |
| General subdivision | S. haemolyticus |
| General subdivision | icaC virulence genes |
| General subdivision | genes for AMR |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Fuller form of name | Martha F. Mushi |
| Fuller form of name | Arun Gonzales Decano |
| Fuller form of name | Jeremiah Seni |
| Fuller form of name | Blandina T. Mmbaga |
| Fuller form of name | Happiness Kumburu |
| Fuller form of name | Eveline T. Konje |
| Fuller form of name | Joseph R. Mwanga |
| Fuller form of name | Benson R. Kidenya |
| Fuller form of name | Betrand Msemwa |
| Fuller form of name | Stephen Gillespie |
| Fuller form of name | Antonio Maldonado-Barragan |
| Fuller form of name | Alison Sandeman |
| Fuller form of name | Wilber Sabiti |
| Fuller form of name | Mathew T. G. Holden |
| Fuller form of name | Stephen E. Mshana |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.3390/pathogens12020180">https://doi.org/10.3390/pathogens12020180</a> |
| Link text | https://doi.org/10.3390/pathogens12020180 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | ddc |
| Koha item type | RESEARCH ARTICLES |
| Suppress in OPAC | |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Date acquired | Total checkouts | Barcode | Date last seen | Price effective from | Koha item type |
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| MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | 06/07/2024 | 20240607192123.0 | 06/07/2024 | 06/07/2024 | RESEARCH ARTICLES |