Burkitt lymphoma risk shows geographic and temporal associations with Plasmodium falciparum infections in Uganda, Tanzania, and Kenya (Record no. 27936)
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| fixed length control field | 03063nam a22004937a 4500 |
| 001 - CONTROL NUMBER | |
| control field | 20240606121208.0 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | 20240606121208.0 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20240606122107.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 240606b |||||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | ddc |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | English |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Fuller form of name | Broen K, |
| 245 ## - TITLE STATEMENT | |
| Title | Burkitt lymphoma risk shows geographic and temporal associations with Plasmodium falciparum infections in Uganda, Tanzania, and Kenya |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mwanza, Tanzania : |
| Name of publisher, distributor, etc. | Catholic University of Health and Allied Sciences [CUHAS – Bugando] : |
| Date of publication, distribution, etc. | 2023 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | Pages 01-09 |
| Extent | Includes References |
| 490 ## - SERIES STATEMENT | |
| Series statement | PNAS 2023 Vol. 120 No. 2 e2211055120 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Abstract :<br/><br/>Endemic Burkitt lymphoma (eBL) is a pediatric cancer coendemic with malaria in sub-Saharan Africa, suggesting an etiological link between them. However, previous cross-sectional studies of limited geographic areas have not found a convincing association. We used spatially detailed data from the Epidemiology of Burkitt Lymphoma in East African Children and Minors (EMBLEM) study to assess this relationship. EMBLEM is a case–control study of eBL from 2010 through 2016 in six regions of Kenya, Uganda, and Tanzania. To measure the intensity of exposure to the malaria parasite, Plasmodium falciparum, among children in these regions, we used high-resolution spatial data from the Malaria Atlas Project to estimate the annual number of P. falciparum infections from 2000 through 2016 for each of 49 districts within the study region. Cumulative P. falciparum exposure, calculated as the sum of annual infections by birth cohort, varied widely, with a median of 47 estimated infections per child by age 10, ranging from 4 to 315 infections. eBL incidence increased 39% for each 100 additional lifetime P. falciparum infections (95% CI: 6.10 to 81.04%) with the risk peaking among children aged 5 to 11 and declining thereafter. Alternative models using estimated annual P. falciparum infections 0 to 10 y before eBL onset were inconclusive, suggesting that eBL risk is a function of cumulative rather than recent cross-sectional exposure. Our findings provide population-level evidence that eBL is a phenotype related to heavy lifetime exposure to P. falciparum malaria and support emphasizing the link between malaria and eBL.<br/>Continue Reading |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Fuller form of name | Zelner J |
| Fuller form of name | Mbulaiteye SM |
| Fuller form of name | Wilson ML |
| Fuller form of name | Goedert JJ |
| Fuller form of name | Biggar RJ |
| Fuller form of name | Bhatia K |
| Fuller form of name | Ayers LW |
| Fuller form of name | Buller ID |
| Fuller form of name | Nabalende H |
| Fuller form of name | Legason ID |
| Fuller form of name | Otim I |
| Fuller form of name | Kinyera T |
| Fuller form of name | Wekesa WN |
| Fuller form of name | Kuremu RT |
| Fuller form of name | Were PA |
| Fuller form of name | Kerchan P |
| Fuller form of name | Kawira E |
| Fuller form of name | Reynolds SJ |
| Fuller form of name | Masalu N |
| Fuller form of name | Tenge CN |
| Fuller form of name | Ogwang MD |
| Fuller form of name | Trangucci R |
| Fuller form of name | Dickens J |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1073/pnas.2211055120">https://doi.org/10.1073/pnas.2211055120</a> |
| Link text | https://doi.org/10.1073/pnas.2211055120 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | ddc |
| Koha item type | RESEARCH ARTICLES |
| Suppress in OPAC | |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Date acquired | Total checkouts | Barcode | Date last seen | Price effective from | Koha item type |
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| MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | 06/06/2024 | 20240606121208.0 | 06/06/2024 | 06/06/2024 | RESEARCH ARTICLES |