Adverse Drug Reactions Profile Among Patients Received Taxane-Based Chemotherapy for Different Cancer Types at Bugando Medical Centre, Mwanza, Tanzania. (Record no. 20942)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03530nam a22003257a 4500 |
| 001 - CONTROL NUMBER | |
| control field | CUHAS/BP/3000281/T/15 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | CUHAS/BP/3000281/T/15 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20240305193841.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210809b |||||||| |||| 00| 0 eng d |
| 028 ## - PUBLISHER OR DISTRIBUTOR NUMBER | |
| Source | Wurzburg Road 35, BMC Premises, Post Code: 33102: |
| Source | P. O. Box 1464, Mwanza – Tanzania: |
| Source | Phone: +255 28 298 3384: |
| Source | Fax: +255 28 298 3386: |
| Source | Email: vc@bugando.ac.tz : |
| Source | www.bugando.ac.tz |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | CUHAS/BP/3000281/T/15 |
| 040 ## - CATALOGING SOURCE | |
| Language of cataloging | English |
| Transcribing agency | DDC |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | English |
| Language code of text/sound track or separate title | Kiswahili |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Shemmela, Hamidu |
| Dates associated with a name | CUHAS/BP/3000281/T/15 |
| 9 (RLIN) | 20946 |
| 245 ## - TITLE STATEMENT | |
| Title | Adverse Drug Reactions Profile Among Patients Received Taxane-Based Chemotherapy for Different Cancer Types at Bugando Medical Centre, Mwanza, Tanzania. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mwanza, Tanzania: |
| Name of publisher, distributor, etc. | Catholic University of Health and Allied Sciences [CUHAS – Bugando] : |
| Date of publication, distribution, etc. | ©2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | x; 22 Pages |
| Extent | Includes References |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Abstract:<br/><br/>Background: Taxanes are class of ant microtubule anticancer agents which originally identified from plants of genus Taxus and they are amongst the most promising antitumor agents available at hand today and they are of increasing importance in worldwide given that cancer is now of the major public health problems which needs to death urgently for the benefit of affected patients. Taxanes and taxane-based chemotherapies are associated with ADRs such as peripheral neuropathy, myelosuppression, arthralgia, myalgia and skin reactions that may adversely affect patient-reported quality of life. This toxicity is cumulative across course of therapy, can be a dose-limiting and may lead to dose reaction or cessation of therapy. <br/><br/>Methodology: This was retrospective cross-sectional hospital based study conducted from January 2014 to December 2018. The study involved both inpatients and outpatients who had any cancer type in which taxanes alone or with other chemotherapies were prescribed, and attended at oncology department from January 2014 to December 2018. All retrieved files were observed and obtained data were filled in the data collection tool. <br/><br/>Results: Total of 136 files were retrieved, and found to contain taxane-based chemotherapies and analyzed using SPSS version 20, out of these files, only 117 files were documented for adverse drug reactions, and 104 patients developed ADRs while 13 patients had no complain, while in 19 files the ADRs were documented, and the prevalence of developing ADRs was 88.89%, in which nausea and vomiting, alopecia and peripheral neuropathy were commonly developed by large number of patients compared to other ADRs. <br/><br/>Discussion: This higher prevalence of ADRs could be because of lack of delivering periodic ADR awareness sessions to treating physicians and nurses, lack of active involvement of clinical pharmacies and pharmacists in clinical activities in Bugando medical centre. The documented ADRs are mainly affecting the gastrointestinal tract, bone marrow and skin and this study also pointed out the same. <br/><br/>Conclusion: This study provided basic information regarding the ADRs profile of taxanes bases chemotherapy in variety of cancer types. Nevertheless, early detection of these ADRs may help in minimizing the damage by either modifying the dose or changing the medications. <br/> |
| 600 ## - SUBJECT ADDED ENTRY--PERSONAL NAME | |
| General subdivision | Pharmacy |
| General subdivision | Oncology |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 20947 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | ddc |
| Koha item type | UNDERGRADUATE DISSERTATIONS |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | 08/09/2021 | UD0898 | 08/09/2021 | 08/09/2021 | UNDERGRADUATE DISSERTATIONS |