Hematological Indices Among Paediatric Cancer Patients Undergoing Chemotherapy at Bugando Medical Centre in Mwanza, Tanzania. (Record no. 20883)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03620nam a22003497a 4500 |
| 001 - CONTROL NUMBER | |
| control field | CUHAS/BM/1000330/T/16 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | CUHAS/BM/1000330/T/16 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20240305193837.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210809b |||||||| |||| 00| 0 eng d |
| 028 ## - PUBLISHER OR DISTRIBUTOR NUMBER | |
| Source | Wurzburg Road 35, BMC Premises, Post Code: 33102: |
| Source | P. O. Box 1464, Mwanza – Tanzania: |
| Source | Phone: +255 28 298 3384: |
| Source | Fax: +255 28 298 3386: |
| Source | Email: vc@bugando.ac.tz : |
| Source | www.bugando.ac.tz |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | CUHAS/BM/1000330/T/16 |
| 040 ## - CATALOGING SOURCE | |
| Language of cataloging | English |
| Transcribing agency | DDC |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | English |
| Language code of text/sound track or separate title | Kiswahili |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mrimi, Abraham. Jeremiah |
| Dates associated with a name | CUHAS/BM/1000330/T/16 |
| 9 (RLIN) | 20854 |
| 245 ## - TITLE STATEMENT | |
| Title | Hematological Indices Among Paediatric Cancer Patients Undergoing Chemotherapy at Bugando Medical Centre in Mwanza, Tanzania. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mwanza, Tanzania: |
| Name of publisher, distributor, etc. | Catholic University of Health and Allied Sciences [CUHAS – Bugando] : |
| Date of publication, distribution, etc. | ©2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | viii; 27 Pages |
| Extent | Includes References |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Abstract:<br/><br/>Background: Chemotherapy is useful in treating malignant diseases. Among pediatric cancer patients in Tanzania, no published data explains their baseline hematological indices and how such indices change over time while on chemotherapy treatment. <br/><br/>Objective: This study aimed to determine the baseline hematological indices among pediatric cancer patients attending Bugando medical centre (BMC) and how such indices change while on chemotherapy.<br/><br/>Methodology: A combined retrospective- prospective cross-sectional study was conducted at Bugando medical centre from January to August 2019. Sixty nine new pediatric cancer cases and 52 healthy controls were tested for baseline hematological indices, then 30/69 cases were prospectively followed after only one cycle of chemotherapy to obtain similar indices using the DH 76 auto hematology analyzer. Data was analyzed using Microsoft Excel.<br/><br/>Results: Participants were aged between 0-18 years old. Out of 52 controls, 28 (53.8%) were female while among cases, 39 (56.5%) were female. The most prevalent cancer type was Wilm’s tumor followed by retinoblastoma. At baseline, control’s mean (SD) Hb and MCV were significantly lower while total WBC count and ANC indices were comparably higher than among cases with the most effect on the highest age group (11.6 (2.1) g/dl, 75 (10.4) µm3 , 3.48 (2.2) x 109 /1 and 8.37 (4.2) x 109/1 versus 9.7 (3.4) g/dl, 69.5 (11) µm3, 5.6 (5.65) x 109/1 and 11.36 (9.22) x 109/1 respectively (p = 0.0072, 0.0091, 0.013 and 0.032 respectively). Microcytosis, leukocytosis, thrombopenia, thrombocytosis and moderate to severe anemia were more prevalent in cases than in controls. After one cycle of chemotherapy, only total WBC count significantly decreased compared to other indices (9.76 (6.65) x 109/1 to 6.67 (3.76) x 109/1, p=0.03) with vincristine and cyclophosphamide based regimens significantly decreasing neutrophils and total WBC respectively (5.02 (34) x 109/1 to 3.16 (2.61) x 109/1, p =0.04 and 11.73 (4.9) x 109/1 to 5.8 (3.66) x 109/1. P =0.03 respectively.<br/><br/>Conclusion: Haematological outcomes were poor among cancer patients compared with healthy controls. Chemotherapy use were significantly associated with a reduction of total leukocyte count, with Vincristine and cyclophosphamide based regimens increasing this effect. <br/> |
| 600 ## - SUBJECT ADDED ENTRY--PERSONAL NAME | |
| General subdivision | Medical Laboratory Sciences |
| General subdivision | Public Health |
| General subdivision | Biochemistry and Molecular Biology |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 20853 |
| 9 (RLIN) | 20827 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | ddc |
| Koha item type | UNDERGRADUATE DISSERTATIONS |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | 08/09/2021 | UD0839 | 08/09/2021 | 08/09/2021 | UNDERGRADUATE DISSERTATIONS |