Prior undernutrition and insulin production several years later in Tanzanian adults (Record no. 19941)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03668nam a22003737a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20240305193746.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 221206b |||||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| Source | American Society for Nutrition |
| International Standard Serial Number | Online ISSN 1938-3207 |
| Source | American Society for Nutrition |
| International Standard Serial Number | Print ISSN 0002-9165 |
| 028 ## - PUBLISHER OR DISTRIBUTOR NUMBER | |
| Source | Phone: +255 28 298 3384 |
| Source | Fax: +255 28 298 3386 |
| Source | Email: vc@bugando.ac.tz |
| Source | Website: www.bugando.ac.tz |
| 040 ## - CATALOGING SOURCE | |
| Language of cataloging | English |
| Transcribing agency | DLC |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | English |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Suzanne Filteau |
| 9 (RLIN) | 46724 |
| 222 ## - KEY TITLE | |
| Key title | malnutrition-associated diabetes, HIV, Tanzania, insulin, glucose tolerance |
| Qualifying information | malnutrition-associated diabetes, HIV, Tanzania, insulin, glucose tolerance |
| Key title | hiv body mass index procedure diabetes mellitus diabetes mellitus, type 2 glucose adult malnutrition insulin oral glucose tolerance test |
| Key title | Original Research Communications |
| 245 ## - TITLE STATEMENT | |
| Title | Prior undernutrition and insulin production several years later in Tanzanian adults |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mwanza, Tanzania: |
| Name of publisher, distributor, etc. | Oxford University Press & |
| -- | Catholic University of Health and Allied Sciences [CUHAS – Bugando] |
| Date of publication, distribution, etc. | 2021/6 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | Pages 1600-1608 |
| 490 ## - SERIES STATEMENT | |
| Volume/sequential designation | The American journal of clinical nutrition Volume 113 Issue 6 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | ABSTRACT:<br/><br/>Background: The prevalence, pathology, and existence of malnutrition-associated diabetes remain uncertain, especially with respect to adult-acquired undernutrition.<br/><br/>Objective: The aim was to investigate the association of prior undernutrition (low BMI, in kg/m2), acquired in adulthood and insulin during an oral glucose tolerance test (OGTT).<br/><br/>Methods: We followed up 630 adults recruited 7–14 y previously for other studies. Plasma insulin was measured fasting and at 30 and 120 min during an OGTT. The main exposure was BMI measured 7–14 y prior. The main outcome of interest was plasma insulin, controlling for time during the OGTT using generalized estimating equations, and exploratory outcomes were early insulin response (relative change in insulin and glucose from 0–30 min) and relative insulin and glucose AUCs from 0 to 120 min. Current confounding factors were age, sex, BMI, HIV, socioeconomic status, and physical activity.<br/><br/>Results: In unadjusted analyses, increasing severity of prior malnutrition was associated with lower insulin concentration. In multivariate adjusted analyses, only current BMI was a strong predictor of overall insulin concentration. Associations with prior BMI of insulin responses accounting for glucose were also seen in unadjusted but not adjusted analyses. For insulin concentration but not the outcomes accounting for glucose, there was a sex interaction with prior BMI such that only men had lower insulin if previously malnourished: insulin (pmol/L) at 120 min was 311 (95% CI: 272, 351) for prior BMI ≥18.5, 271 (95% CI: 221, 321) for prior BMI 17.0–18.5, and 237 (95% CI: 194, 297) for prior BMI <17.0; P = 0.03. HIV status showed limited and variable associations with insulin.<br/><br/>Conclusions: Insulin concentration, fasting and during an OGTT, was normalized in women more than in men several years after adult malnutrition. Chronic malnutrition, as indicated by low prior and current BMI, may contribute to diabetes through low insulin secretion. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 46773 |
| 9 (RLIN) | 46774 |
| 9 (RLIN) | 46775 |
| 9 (RLIN) | 22817 |
| 9 (RLIN) | 46776 |
| 9 (RLIN) | 23081 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1093/ajcn/nqaa438">https://doi.org/10.1093/ajcn/nqaa438</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | ddc |
| Koha item type | RESEARCH ARTICLES |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Barcode | Date last seen | Copy number | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | 12/06/2022 | RA1149 | 12/06/2022 | RA1149 | 12/06/2022 | RESEARCH ARTICLES |