Blood pressure and mortality in a prospective cohort of HIV-infected adults in Port-au-Prince, Haiti (Record no. 19934)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02979nam a22003257a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20240305193746.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 221206b |||||||| |||| 00| 0 eng d |
| 028 ## - PUBLISHER OR DISTRIBUTOR NUMBER | |
| Source | Phone: +255 28 298 3384 |
| Source | Fax: +255 28 298 3386 |
| Source | Email: vc@bugando.ac.tz |
| Source | Website: www.bugando.ac.tz |
| 040 ## - CATALOGING SOURCE | |
| Language of cataloging | English |
| Transcribing agency | DLC |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | English |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | S Ashita |
| 9 (RLIN) | 46741 |
| 222 ## - KEY TITLE | |
| Key title | HIV, mortality, hypertension, interleukin-6, inflammation, Haiti |
| 245 ## - TITLE STATEMENT | |
| Title | Blood pressure and mortality in a prospective cohort of HIV-infected adults in Port-au-Prince, Haiti |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mwanza, Tanzania: |
| Name of publisher, distributor, etc. | NIH Public Access & |
| -- | Catholic University of Health and Allied Sciences [CUHAS – Bugando] |
| Date of publication, distribution, etc. | 2018/7 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | Pages 1533 |
| 490 ## - SERIES STATEMENT | |
| Volume/sequential designation | Journal of hypertension Volume 36 Issue 7 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Abstract:<br/><br/>Objective: The objective of this study was to determine how baseline blood pressure and incident hypertension related to antiretroviral therapy (ART) initiation, HIV-related inflammation, and mortality in HIV-infected adults in a low-income country.<br/><br/>Methods: We conducted long-term follow-up of HIV-infected adults who had participated in a trial of early versus delayed initiation of ART in Port-au-Prince, Haiti. Between 2005-2008, 816 HIV-infected adults were randomized to early (N=408) versus delayed ART (when CD4<200 cells/mm3 or AIDS-defining condition; N=408). Blood pressure was measured every 3 months. Hypertension was diagnosed according to the Joint National Committee (JNC-7) guidelines. Biomarkers of inflammation and coagulation were measured from banked enrollment plasma samples. Survival analyses were performed using Stata 14.<br/><br/>Results: The median age at enrollment was 39 years. The median follow-up time was 7.3 years. The hypertension incidence rate was 3.41 per 100 person years, and was similar in early and delayed ART groups. In multivariable models, independent predictors of incident hypertension were older age, higher BMI, and plasma IL-6 levels (adjusted hazard ratio, aHR=1.23, p<0.001). Systolic pressure >140mmHg at enrollment was associated with increased mortality (aHR=2.47, p=0.03) as was systolic pressure <90mmHg (aHR=2.25, p=0.04). Prevalent and incident hypertension were also significantly associated with mortality.<br/><br/>Conclusions: In a large prospective study of HIV-infected adults we found a high incidence of hypertension associated with HIV-related inflammation. Baseline hypertension conferred a >2-fold increased risk of death. Among HIV-infected adults in low-income countries, hypertension should be considered a serious threat to long-term survival. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 46617 |
| 9 (RLIN) | 23036 |
| 9 (RLIN) | 45156 |
| 9 (RLIN) | 46742 |
| 9 (RLIN) | 46743 |
| 9 (RLIN) | 45159 |
| 9 (RLIN) | 45944 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | ddc |
| Koha item type | RESEARCH ARTICLES |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Barcode | Date last seen | Copy number | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | 12/06/2022 | RA1142 | 12/06/2022 | RA1142 | 12/06/2022 | RESEARCH ARTICLES |