Para-aminosalicylic acid plasma concentrations in children in comparison with adults after receiving a granular slow-release preparation (Record no. 19705)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02227nam a22003377a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20240305193737.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 221125b |||||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | Online ISSN 1465-3664 |
| 028 ## - PUBLISHER OR DISTRIBUTOR NUMBER | |
| Source | Phone: +255 28 298 3384 |
| Source | Fax: +255 28 298 3386 |
| Source | Email: vc@bugando.ac.tz |
| Source | Website: www.bugando.ac.tz |
| 040 ## - CATALOGING SOURCE | |
| Language of cataloging | English |
| Transcribing agency | DLC |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | English |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | AC Liwa |
| 9 (RLIN) | 45987 |
| 222 ## - KEY TITLE | |
| Key title | para-aminosalicylic acid, pharmacokinetics, children |
| Key title | plasma drug concentration high pressure liquid chromatography procedure p-aminosalicylic acid |
| 245 ## - TITLE STATEMENT | |
| Title | Para-aminosalicylic acid plasma concentrations in children in comparison with adults after receiving a granular slow-release preparation |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mwanza, Tanzania: |
| Name of publisher, distributor, etc. | Oxford University Press & |
| -- | Catholic University of Health and Allied Sciences [CUHAS – Bugando] |
| Date of publication, distribution, etc. | 2013/4/1 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | Pages 90-94 |
| 490 ## - SERIES STATEMENT | |
| Volume/sequential designation | Journal of tropical pediatrics Volume 59 Issue 2 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Abstract::::<br/>There are no paediatric data regarding slow-release para-aminosalicylic acid (PAS). We studied PAS plasma concentrations in 10 children receiving a single 150 mg/kg dose daily or 75 mg/kg twice daily and 12 adults receiving 4 g twice daily. Blood specimens pre-dose and 2, 4, 6, 8 and 12 h post-dose from the children and 2, 3, 4, 5, 6, 8 and 12 h post-dose from the adults were analysed by high performance liquid chromatography MS/MS. The mean Cmax in children receiving PAS 75 mg/kg and 150 mg/kg and adults receiving 4 g was 45.40, 56.49 and 51.3 µg/ml, respectively (p = 0.614); the AUC0–12 was 233.3, 277.9 and 368.0 µg/h/ml (p = 0.587). No parameters differed significantly between children and adults nor between the two doses in the same children. A 150 mg/kg PAS dosage given as one or two daily doses leads to plasma concentrations in children similar to those of adults receiving 4 g PAS twice daily. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 45989 |
| 9 (RLIN) | 45990 |
| 9 (RLIN) | 45991 |
| 9 (RLIN) | 45992 |
| 9 (RLIN) | 45993 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1093/tropej/fms053">https://doi.org/10.1093/tropej/fms053</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | ddc |
| Koha item type | RESEARCH ARTICLES |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Barcode | Date last seen | Copy number | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | 11/25/2022 | RA0913 | 11/25/2022 | RA0913 | 11/25/2022 | RESEARCH ARTICLES |