HIV p24 Antigen Assay in the Diagnosis of Immunological Failure Among Patients with HIV Infection in Mwanza City. MJ HIV. 2 (1): 016 (Record no. 19652)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03875nam a22002897a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20240305193735.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 221123b |||||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 2474-6916 |
| 028 ## - PUBLISHER OR DISTRIBUTOR NUMBER | |
| Source | Phone: +255 28 298 3384 |
| Source | Fax: +255 28 298 3386 |
| Source | Email: vc@bugando.ac.tz |
| Source | Website: www.bugando.ac.tz |
| 040 ## - CATALOGING SOURCE | |
| Language of cataloging | English |
| Transcribing agency | DLC |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | English |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | E Kamugisha |
| 9 (RLIN) | 23593 |
| 222 ## - KEY TITLE | |
| Key title | p24 antigen assay; Immunological failure; Virological failure; Mwanza; Tanzania. |
| 245 ## - TITLE STATEMENT | |
| Title | HIV p24 Antigen Assay in the Diagnosis of Immunological Failure Among Patients with HIV Infection in Mwanza City. MJ HIV. 2 (1): 016 |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mwanza, Tanzania: |
| Name of publisher, distributor, etc. | MJ HIV & |
| -- | Catholic University of Health and Allied Sciences [CUHAS – Bugando] |
| Date of publication, distribution, etc. | 08 Dec 2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | Pages 1-8 |
| 490 ## - SERIES STATEMENT | |
| Volume/sequential designation | Citation: Kamugisha E, Kidola J and Mshana SE.(2017). HIV p24 Antigen Assay in the Diagnosis of Immunological Failure Among Patients with HIV Infection in Mwanza City. MJ HIV Volume 2 Issue 1 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | ABSTRACT:<br/><br/>Background: Despite the great efforts to expand anti-retroviral therapy (ART) services in Tanzania since 2004, data shows that the proportion of patients on second line is still very low. This may be due to the fact that patients who fail the first line are not recognized in time.In a resource limited country like Tanzania quantification of the human immunodeficiency virus type 1 (HIV-1) RNA levels (viral load) in plasma is limited. This is due to lack of enough health facilities to performreal-time<br/>based PCR assays.This study aimed at evaluating an Ultrasensitivep24 antigen assay as a potential alternative to HIV-1 RNA viral load assay.<br/><br/>Methodology: HIV infected patients attending care and treatment clinics in selected Mwanza city hospitals (Buzuruga, Nyamagana and Sekou-Toure) were recruited. Aseptic venipuncture wasdone to obtain 5mls of blood. This was used for p24 antigen assay, viral load assay and CD4 determination. Laboratory results were then compared to detect the utility of p24 assay compared to real time based PCR assay in establishment of immunological failure.<br/><br/>Results: A total of 270 HIV- infected participants were recruited (192 ART naïve and 78 (29%) on ART). HIV experienced ART had lower median (IQR) p24 antigen level of 3.4 (1.53; 4.43) pg/mL compared to 10.6 (3.34; 39.32) pg/mL median p24 antigen level of HIV ARV naïve. In the period of 6 months and above of being on ARV, 14.5 % of the participants were categorized as immunological failure while virological suppressions was 69.2 %. CD4+ lymphocyte count at recruitment andheat denatured p24 antigen level were significantly correlated with each other (r = -0.38; 95%CI, -0.48; -0.27, p<0.001). The gradual increase of p24 antigen level with time correlated with an increase of proportion of immunological failure. Only CD4+ lymphocyte was highly predicative of subsequent immunological failure. In cox multivariate models the age and CD4+ lymphocyte were factors that were highly predictive of subsequent immunological failure.<br/><br/>Conclusions: p24 antigen level in our study population was well correlated with CD4 lymphocyte count. The rise in p24 antigen levels was correlated with the proportion of immunological failure. Although p24 was not found to be statistically significant predictor of immunological failure but its correlation with CD4 count still makes it a useful indicator of immunological failure. p24 antigen assay can easily be measured in our resource limited environment with minimum challenges. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 45878 |
| 9 (RLIN) | 23705 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://www.mathewsopenaccess.com/scholarly-articles/hiv-p24-antigen-assay-in-the-diagnosis-of-immunological-failure-among-patients-with-hiv-infection-in-mwanza-city.pdf">https://www.mathewsopenaccess.com/scholarly-articles/hiv-p24-antigen-assay-in-the-diagnosis-of-immunological-failure-among-patients-with-hiv-infection-in-mwanza-city.pdf</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | ddc |
| Koha item type | RESEARCH ARTICLES |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Barcode | Date last seen | Copy number | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | 11/23/2022 | RA0860 | 11/23/2022 | RA0860 | 11/23/2022 | RESEARCH ARTICLES |