Extended Spectrum Beta-Lactamase Producing Enterobacteriaceae Associated with Asymptomatic Bacteriuria among Pregnant Women Attending Antenatal Clinic at Tertiary Referral Hospital, Tanzania (Record no. 19634)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03928nam a22003377a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20240305193734.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 221123b |||||||| |||| 00| 0 eng d |
| 028 ## - PUBLISHER OR DISTRIBUTOR NUMBER | |
| Source | Phone: +255 28 298 3384 |
| Source | Fax: +255 28 298 3386 |
| Source | Email: vc@bugando.ac.tz |
| Source | Website: www.bugando.ac.tz |
| 040 ## - CATALOGING SOURCE | |
| Language of cataloging | English |
| Transcribing agency | DLC |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | English |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Doreen Kamori |
| 9 (RLIN) | 45771 |
| 222 ## - KEY TITLE | |
| Key title | Pregnancy, Asymptomatic bacteriuria, Extended Spectrum Beta-Lactamase, Enterobacteriaceae, Resistance |
| 245 ## - TITLE STATEMENT | |
| Title | Extended Spectrum Beta-Lactamase Producing Enterobacteriaceae Associated with Asymptomatic Bacteriuria among Pregnant Women Attending Antenatal Clinic at Tertiary Referral Hospital, Tanzania |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mwanza, Tanzania: |
| Name of publisher, distributor, etc. | Tanzania Medical Journal & |
| -- | Catholic University of Health and Allied Sciences [CUHAS – Bugando] |
| Date of publication, distribution, etc. | 2022/1/31 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | Pages 75-92 |
| 490 ## - SERIES STATEMENT | |
| Volume/sequential designation | Tanzania Medical Journal Volume 33 Issue 1 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | <br/>Abstract:<br/><br/>Background: Asymptomatic bacteriuria occurs in 2-15% of pregnancies resulting in acute pyelonephritis, preterm labor, pre-eclampsia, anemia, amnionitis, low birth weight, stillbirths, bacteremia and toxic septicemia. Asymptomatic bacteriuria in pregnancy (ASBP) caused by extended-spectrum beta-lactamases producing Enterobacteriaceae (ESBL-PE) further complicates the health of a pregnant woman, affecting treatment and spread of resistant bacteria strains to newborns and the community. However, in Tanzania, screening for resistant bacteria such as ESBL-PE in ASBP is not routinely done.<br/><br/>Broad objective: To determine the prevalence of ASBP associated with ESBL-PE and the antimicrobial susceptibility pattern of ESBL-PE isolated from pregnant women at Muhimbili National Hospital (MNH) in Dar es salaam, Tanzania.<br/><br/>Methodology: A hospital-based cross-sectional study was conducted at MNH. A total of 182 pregnant women with the gestational age of 37 weeks and above were enrolled. A semi-structured questionnaire and antenatal cards were used to collect socio-demographic and pregnancy information. Clean catch mid-stream urine was collected for screening of asymptomatic bacteriuria. Bacteria were identified using conventional biochemical methods and antimicrobial susceptibility testing (AST) was performed by Kirby-Bauer method following Clinical Laboratory Standard Institute (CLSI) guidelines. The isolates resistant to ceftazidime and cefotaxime were confirmed for ESBL production using a double-disc synergy test (DDST).<br/><br/>Results: Asymptomatic bacteriuria was observed in 13% (24/182) of the pregnant women attending antenatal clinic at MNH. We report that, 61.9% (13/21) of women with asymptomatic bacteriuria associated with gram negative bacteria were infected with ESBL-PE. Among the ESBL-PE species mostly isolated include E. coli (69.2%), followed by K. pneumoniae (23.1%), and K. oxytoca (7.7%); and non ESBL-PE species isolated were E. coli (87.5.6%), and K. pneumoniae (12.5%). In addition, three S. aureus isolates were detected in women with ASBP. ESBL-PE isolates showed high resistance to aztreonam, sulphamethoxazole-trimethoprim, amikacin and nalidixic acid; while for the few detected non ESBL-PE high resistance was seen to sulphamethoxazole-trimethoprim, aztreonam, meropenem and nalidixic acid.<br/><br/>Â Conclusion and recommendation: The present study revealed that a high proportion of bacteriuria in pregnancy is associated with ESBL-PE. These findings suggest a need for screening of resistant bacteria such as ESBL in cases of ASBP.<br/> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 45839 |
| 9 (RLIN) | 45840 |
| 9 (RLIN) | 45841 |
| 9 (RLIN) | 22927 |
| 9 (RLIN) | 15820 |
| 9 (RLIN) | 45576 |
| 9 (RLIN) | 22970 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.4314/tmj.v33i1.522">https://doi.org/10.4314/tmj.v33i1.522</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | ddc |
| Koha item type | RESEARCH ARTICLES |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Date last seen | Copy number | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | 11/23/2022 | 11/23/2022 | RA0842 | 11/23/2022 | RESEARCH ARTICLES |