Enterobacter bugandensis (Record no. 19541)
[ view plain ]
| 000 -LEADER | |
|---|---|
| fixed length control field | 03301nam a22005057a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20240305193731.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 221121b |||||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 2045-2322 (online) |
| 028 ## - PUBLISHER OR DISTRIBUTOR NUMBER | |
| Source | Phone: +255 28 298 3384 |
| Source | Fax: +255 28 298 3386 |
| Source | Email: vc@bugando.ac.tz |
| Source | Website: www.bugando.ac.tz |
| 040 ## - CATALOGING SOURCE | |
| Language of cataloging | English |
| Transcribing agency | DLC |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | English |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Niladri Bhusan Pati |
| 9 (RLIN) | 45607 |
| 222 ## - KEY TITLE | |
| Key title | Bacterial evolution Bacterial genomics Bacterial pathogenesis Infectious-disease epidemiology |
| 245 ## - TITLE STATEMENT | |
| Title | Enterobacter bugandensis |
| Remainder of title | a novel enterobacterial species associated with severe clinical infection |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mwanza, Tanzania: |
| Name of publisher, distributor, etc. | Nature Publishing Group & |
| -- | Catholic University of Health and Allied Sciences [CUHAS – Bugando] |
| Date of publication, distribution, etc. | 2018/3/29 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | Pages 1-11 |
| 490 ## - SERIES STATEMENT | |
| Volume/sequential designation | Scientific reports Volume 8 Issue 1 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Abstract<br/><br/>Nosocomial pathogens can cause life-threatening infections in neonates and immunocompromised patients. E. bugandensis (EB-247) is a recently described species of Enterobacter, associated with neonatal sepsis. Here we demonstrate that the extended spectrum ß-lactam (ESBL) producing isolate EB-247 is highly virulent in both Galleria mellonella and mouse models of infection. Infection studies in a streptomycin-treated mouse model showed that EB-247 is as efficient as Salmonella Typhimurium in inducing systemic infection and release of proinflammatory cytokines. Sequencing and analysis of the complete genome and plasmid revealed that virulence properties are associated with the chromosome, while antibiotic-resistance genes are exclusively present on a 299 kb IncHI plasmid. EB-247 grew in high concentrations of human serum indicating septicemic potential. Using whole genome-based transcriptome analysis we found 7% of the genome was mobilized for growth in serum. Upregulated genes include those involved in the iron uptake and storage as well as metabolism. The lasso peptide microcin J25 (MccJ25), an inhibitor of iron-uptake and RNA polymerase activity, inhibited EB-247 growth. Our studies indicate that Enterobacter bugandensis is a highly pathogenic species of the genus Enterobacter. Further studies on the colonization and virulence potential of E. bugandensis and its association with septicemic infection is now warranted. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 23153 |
| 9 (RLIN) | 23572 |
| 9 (RLIN) | 15820 |
| 9 (RLIN) | 15822 |
| 9 (RLIN) | 23625 |
| 9 (RLIN) | 23152 |
| 9 (RLIN) | 45608 |
| 9 (RLIN) | 45609 |
| 9 (RLIN) | 45610 |
| 9 (RLIN) | 45611 |
| 9 (RLIN) | 45612 |
| 9 (RLIN) | 45613 |
| 9 (RLIN) | 45614 |
| 9 (RLIN) | 45615 |
| 9 (RLIN) | 45616 |
| 9 (RLIN) | 45617 |
| 9 (RLIN) | 45618 |
| 9 (RLIN) | 45619 |
| 9 (RLIN) | 45620 |
| 9 (RLIN) | 45621 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1038/s41598-018-23069-z">https://doi.org/10.1038/s41598-018-23069-z</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | ddc |
| Koha item type | RESEARCH ARTICLES |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | 11/21/2022 | RA0749 | 11/21/2022 | 11/21/2022 | RESEARCH ARTICLES |