Predictors and outcome of first line treatment failure among under-five children with community acquired severe pneumonia at Bugando Medical Centre, Mwanza, Tanzania (Record no. 19493)

MARC details
000 -LEADER
fixed length control field 03279nam a22002897a 4500
003 - CONTROL NUMBER IDENTIFIER
control field OSt
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20240305193730.0
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028 ## - PUBLISHER OR DISTRIBUTOR NUMBER
Source Phone: +255 28 298 3384
Source Fax: +255 28 298 3386
Source Email: vc@bugando.ac.tz
Source Website: www.bugando.ac.tz
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Transcribing agency DLC
041 ## - LANGUAGE CODE
Language code of text/sound track or separate title English
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Restituta Phabian Muro
9 (RLIN) 23219
245 ## - TITLE STATEMENT
Title Predictors and outcome of first line treatment failure among under-five children with community acquired severe pneumonia at Bugando Medical Centre, Mwanza, Tanzania
Remainder of title A prospective cohort study
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Place of publication, distribution, etc. Mwanza, Tanzania:
Name of publisher, distributor, etc. Public Library of Science &
-- Catholic University of Health and Allied Sciences [CUHAS – Bugando]
Date of publication, distribution, etc. December 11, 2020
300 ## - PHYSICAL DESCRIPTION
Extent Pages e0243636
490 ## - SERIES STATEMENT
Volume/sequential designation PloS one Volume 15 Issue 12
520 ## - SUMMARY, ETC.
Summary, etc. Abstract<br/><br/>Background: Despite recent advances in management and preventive strategies, high rates of first line antibiotics treatment failure and case fatality for Severe Community Acquired Pneumonia (SCAP) continue to occur in children in low and middle-income countries. This study aimed to identify the predictors and outcome of first line antibiotics treatment failure among children under-five years of age with SCAP admitted at Bugando Medical Centre (BMC) in Mwanza, Tanzania.<br/><br/>Methods: The study involved under-five children admitted with SCAP, treated with first line antibiotics as recommended by WHO. Patients with treatment failure at 48 hours were shifted to second line of antibiotics treatment and followed up for 7 days. Generalized linear model was used to determine predictors of first line antibiotics treatment failure for SCAP.<br/><br/>Results: A total of 250 children with SCAP with a median age of 18 [IQR 9–36] months were enrolled, 8.4% had HIV infection and 28% had acute malnutrition. The percentage of first line antibiotics treatment failure for the children with SCAP was 50.4%. Predictors of first line treatment failure were; presentation with convulsion (RR 1.55; 95% CI [1.11–2.16]; p-value 0.009), central cyanosis (RR 1.55; 95% CI [1.16–2.07]; p-value 0.003), low oxygen saturation (RR 1.28; 95% CI [1.01–1.62]; p-value 0.04), abnormal chest X-ray (RR 1.71; 95% CI [1.28–2.29]; p-value <0.001), HIV infection (RR 1.80; 95% CI [1.42–2.27]; p-value 0.001), moderate acute malnutrition (RR 1.48; 95% CI [1.04–2.12]; p-value = 0.030) and severe acute malnutrition (RR 2.02; 95% CI [1.56–2.61]; p-value<0.001). Mortality in children who failed first line treatment was 4.8%.<br/><br/>Conclusion: Half of the children with SCAP at this tertiary center had first line antibiotics treatment failure. HIV infection, acute malnutrition, low oxygen saturation, convulsions, central cyanosis, and abnormal chest X-ray were independently predictive of first line treatment failure. We recommend consideration of second line treatment and clinical trials for patients with SCAP to reduce associated morbidity and mortality.<br/>
700 ## - ADDED ENTRY--PERSONAL NAME
9 (RLIN) 23220
9 (RLIN) 22778
9 (RLIN) 22515
9 (RLIN) 22909
856 ## - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href=" https://doi.org/10.1371/journal.pone.0243636 "> https://doi.org/10.1371/journal.pone.0243636 </a>
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme ddc
Koha item type RESEARCH ARTICLES
Holdings
Withdrawn status Lost status Source of classification or shelving scheme Damaged status Not for loan Collection Home library Current library Shelving location Date acquired Total checkouts Barcode Date last seen Price effective from Koha item type
            MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO   11/18/2022   RA0701 11/21/2022 11/21/2022 RESEARCH ARTICLES
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