Low sensitivity of ParaHIT-f rapid malaria test among patients with fever in rural health centers, Northern Tanzania (Record no. 19281)

MARC details
000 -LEADER
fixed length control field 02887nam a22003497a 4500
003 - CONTROL NUMBER IDENTIFIER
control field OSt
005 - DATE AND TIME OF LATEST TRANSACTION
control field 20240305193721.0
008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION
fixed length control field 221103b |||||||| |||| 00| 0 eng d
022 ## - INTERNATIONAL STANDARD SERIAL NUMBER
International Standard Serial Number 1972-2680
028 ## - PUBLISHER OR DISTRIBUTOR NUMBER
Source Phone: +255 28 298 3384
Source Fax: +255 28 298 3386
Source Email: vc@bugando.ac.tz
Source Website: www.bugando.ac.tz
040 ## - CATALOGING SOURCE
Transcribing agency DLC
041 ## - LANGUAGE CODE
Language code of text/sound track or separate title English
100 ## - MAIN ENTRY--PERSONAL NAME
Personal name Eliningaya John Kweka
9 (RLIN) 45071
222 ## - KEY TITLE
Key title RDT, Plasmodium falciparum, malaria, Tanzania
245 ## - TITLE STATEMENT
Title Low sensitivity of ParaHIT-f rapid malaria test among patients with fever in rural health centers, Northern Tanzania
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Place of publication, distribution, etc. Mwanza:
Name of publisher, distributor, etc. The Journal of Infection in Developing Countries &
-- Tanzania Catholic University of Health and Allied Sciences [CUHAS – Bugando]
Date of publication, distribution, etc. 2011/3/21
300 ## - PHYSICAL DESCRIPTION
Extent Pages 204-208
490 ## - SERIES STATEMENT
Volume/sequential designation The Journal of Infection in Developing Countries Volume 5 Issue 03
520 ## - SUMMARY, ETC.
Summary, etc. Abstract<br/><br/>Introduction: Several rapid diagnostic tools for malaria are currently available in local markets. However, diagnostic accuracy varies widely. The present study was conducted to evaluate a cheaply and easily available rapid diagnostic malaria test (ParaHIT-f) in rural Tanzania.<br/><br/>Methodology: Participants presenting with fever at health centers in the Kilimanjaro and Manyara regions were eligible. Parasitological thin and thick smears were examined from finger-prick blood samples and compared to ParaHIT-f test results. Sensitivity, specificity and predictive values were calculated using microscopic parasitological examination as the gold standard.<br/><br/>Results: In total, 236/743 (31.8%) individuals had a positive malaria microscopy, and 25/715 (3.4%) were positive in the rapid diagnostic test. The sensitivity of ParaHIT-f was 10.7% (95% CI, 6.7-14.7) and specificity was 100% (95% CI, 97.4-102), with positive and negative predictive values (PPV and NPV) of 100% (95% CI, 99.1-100.2) and 70.9% (95% CI, 66.9-74.9) respectively. Sensitivity of ParaHIT-f increased with increasing P. falciparum density (P > 0.003) from 5.8% (95% CI, 0-12.9) at < 100 parasites/μl to 20.5% (95% CI, 13.5-27) at ≥ 100 parasites/μl.<br/><br/>Conclusions: Sensitivity of the ParaHIT-f rapid test was very low in this setting, therefore concomitant use of rapid diagnostic tests and microscopy is recommended. In the case of positive test results, confirmation by parasitological techniques is not necessary. Further monitoring of ParaHIT-f in various epidemiological settings in Tanzania is warranted. <br/>
700 ## - ADDED ENTRY--PERSONAL NAME
9 (RLIN) 45021
9 (RLIN) 45023
9 (RLIN) 45025
9 (RLIN) 45072
9 (RLIN) 45022
9 (RLIN) 45016
9 (RLIN) 22835
856 ## - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="10.3855/jidc.1346">10.3855/jidc.1346</a>
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme ddc
Koha item type RESEARCH ARTICLES
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