Evaluating the appropriateness of chemotherapy in a low‐resource cancer centre in sub‐Saharan Africa (Record no. 19232)

MARC details
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fixed length control field 02897nam a22003497a 4500
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control field OSt
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control field 20240305193719.0
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Source Phone: +255 28 298 3384
Source Fax: +255 28 298 3386
Source Email: vc@bugando.ac.tz
Source Website: www.bugando.ac.tz
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Transcribing agency DLC
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Language code of text/sound track or separate title English
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Personal name Patrizia Serra
9 (RLIN) 44781
245 ## - TITLE STATEMENT
Title Evaluating the appropriateness of chemotherapy in a low‐resource cancer centre in sub‐Saharan Africa
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Place of publication, distribution, etc. Mwanza:
Name of publisher, distributor, etc. John Wiley & Sons, Inc. &
-- Tanzania Catholic University of Health and Allied Sciences [CUHAS – Bugando]
Date of publication, distribution, etc. 13 November 2019
300 ## - PHYSICAL DESCRIPTION
Extent Pages 133-140
490 ## - SERIES STATEMENT
Volume/sequential designation Journal Cancer medicine Volume 9 Issue 1
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Summary, etc. <br/>Abstract<br/><br/>Background<br/><br/>To evaluate the appropriateness of chemotherapy use at the Oncology Department of the Bugando Medical Centre of Mwanza, Tanzania.<br/><br/>Methods<br/><br/>The study was an observational prevalence-based study designed to evaluate a single-chemotherapy cycle during a defined time period for a cross-section of patients at varying stages of their clinical history. The sample included 103 consecutive subjects who were treated during January-March 2017 and had at least one previous cycle. Chemotherapy treatment omissions, cycle delays, and dose reductions and their causes were recorded using a standard form that included demographic, anthropometric, and clinical items. The data were analyzed descriptively.<br/><br/>Results<br/><br/>There were 59 males (57.3%) and 44 females (42.7%). Ninety-four patients were aged ≥18 years. Considering cancer type/site, there were 23 distinct groups of patients. The recorded number of drugs in the chemotherapy regimens varied between one and five. The median cycle number was three (range: 2-11). Sixty-eight (66.0%) patients were treated in a standard fashion. For the remaining, cycle delay and dose reduction were the most common cause for nonstandard treatment. Hematologic toxicity was responsible for the greater part of cycle delays, whereas dose reductions were accounted for by a larger spectrum of causes. Overall, toxicity explained 21/35 (60.0%) patients receiving nonstandard treatment. The distribution of toxic events was skewed toward grade 1 and grade 2.<br/><br/>Conclusions<br/><br/>The observed level of appropriateness of chemotherapy was encouraging. The proportion of patients experiencing severe toxic effects was lower than expected.<br/>
700 ## - ADDED ENTRY--PERSONAL NAME
9 (RLIN) 44838
9 (RLIN) 22884
9 (RLIN) 44945
9 (RLIN) 44958
9 (RLIN) 44959
9 (RLIN) 44782
9 (RLIN) 44960
9 (RLIN) 44961
9 (RLIN) 44962
856 ## - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href=" https://doi.org/10.1002/cam4.2672"> https://doi.org/10.1002/cam4.2672</a>
942 ## - ADDED ENTRY ELEMENTS (KOHA)
Source of classification or shelving scheme ddc
Koha item type RESEARCH ARTICLES
Holdings
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