Prevalence of clindamycin inducible resistance among methicillin-resistant Staphylococcus aureus at Bugando Medical Centre, Mwanza, Tanzania (Record no. 19134)
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| 000 -LEADER | |
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| fixed length control field | 03108nam a22003377a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20240305193716.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 221011b |||||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | eISSN: 1821-9241 |
| International Standard Serial Number | print ISSN: 1821-6404 |
| 028 ## - PUBLISHER OR DISTRIBUTOR NUMBER | |
| Source | Phone: +255 28 298 3384 |
| Source | Fax: +255 28 298 3386 |
| Source | Email: vc@bugando.ac.tz |
| Source | Website: www.bugando.ac.tz |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | DLC |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | English |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | SE Mshana |
| 9 (RLIN) | 23705 |
| 222 ## - KEY TITLE | |
| Key title | prevalence, clindamycin, methicillin-resistant, Staphylococcus aureus, Tanzania |
| 245 ## - TITLE STATEMENT | |
| Title | Prevalence of clindamycin inducible resistance among methicillin-resistant Staphylococcus aureus at Bugando Medical Centre, Mwanza, Tanzania |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mwanza, Tanzania: |
| Name of publisher, distributor, etc. | Tanzania Journal of Health Research & |
| -- | Catholic University of Health and Allied Sciences [CUHAS – Bugando] |
| Date of publication, distribution, etc. | 2009 |
| 490 ## - SERIES STATEMENT | |
| Volume/sequential designation | Tanzania Journal of Health Research Volume 11 Issue 2 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Abstract<br/><br/>Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) has been recognized world wide as an important causative agent of nosocomial and community acquired infections. Clindamycin has been considered as an<br/>alternative drug for the treatment of such strains. However, the possibility of clindamycin inducible resistance complicates the choice of treatment. The aim of this study was to determine the prevalence of clindamycin<br/>inducible resistance of MRSA at Bugando Medical Centre (BMC) in Mwanza Tanzania. A total of 600 clinical specimens of pus, wound swabs and aspirates from patients admitted at BMC surgical wards were processed<br/>over a period of 4 months. Of these, 160 of S. aureus clinical isolates were analysed. MRSA was identified using cefoxitin disc, oxacillin disc and oxacillin agar. Inducible clindamycin resistance was detected using<br/>erythromycin (15μg) and clindamycin (2μg) discs placed 15mm apart on Muller Hinton agar. Of the 160 isolates, 26 (16.3%) were found to be MRSA. Overall prevalence of inducible clindamycin resistance (iMLSB)<br/>was 28.8% (46/160), with 22% (30/134) of methicillin-susceptible S. aureus (MSSA) and 61% (16/26) of MRSA exhibiting inducible clindamycin resistance (P=0.0001). Constitutive resistance (cMLSB) was found in 1 (3.7%) of the MRSA isolates and was not detected among MSSA. MSB phenotype was detected in 1 (3.8%) of MRSA isolates and 2 (1.5%) of MSSA. Eight (29.6%) of the MRSA isolates were sensitive to both clindamycin and erythromycin. In conclusion, a high prevalence of inducible clindamycin resistance was observed among S. aureus with significant association between MRSA and inducible clindamycin resistance. It is important that susceptibility test of staphylococci is routinely done to facilitate early detection of clindamycin inducible resistance in the country. |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 23593 |
| 9 (RLIN) | 23597 |
| 9 (RLIN) | 44625 |
| 9 (RLIN) | 23596 |
| 9 (RLIN) | 44626 |
| 9 (RLIN) | 44627 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Link text | https://doi.org/10.4314/thrb.v11i2.45197 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | ddc |
| Koha item type | RESEARCH ARTICLES |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | 10/11/2022 | RA0333 | 10/11/2022 | 10/11/2022 | RESEARCH ARTICLES |