CA-MRSA and HA-MRSA coexist in community and hospital settings in Uganda (Record no. 19025)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03121nam a22003137a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210826b |||||||| |||| 00| 0 eng d |
| 022 ## - INTERNATIONAL STANDARD SERIAL NUMBER | |
| International Standard Serial Number | 2047-2994 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | David Patrick Kateete |
| 9 (RLIN) | 23720 |
| 222 ## - KEY TITLE | |
| Key title | Eastern Uganda; Iganga/Mayuge districts; Coexistence; Hospital-associated MRSA; Community-associated MRSA; mecA; SCCmec types; spa types |
| 245 ## - TITLE STATEMENT | |
| Title | CA-MRSA and HA-MRSA coexist in community and hospital settings in Uganda |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mwanza, Tanzania: |
| Name of publisher, distributor, etc. | Catholic University of Health and Allied Sciences CUHAS - Bugando & |
| -- | BioMed Central |
| Date of publication, distribution, etc. | 03 June 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | Pages 1-9 |
| 490 ## - SERIES STATEMENT | |
| Volume/sequential designation | Antimicrobial Resistance & Infection Control Volume 8 Issue 1 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Abstract<br/><br/>Background: Methicillin resistant Staphylococcus aureus (MRSA) strains were once confined to hospitals however, in the last 20 years MRSA infections have emerged in the community in people with no prior exposure to hospitals. Strains causing such infections were novel and referred to as community-associated MRSA (CA-MRSA). The aim of this study was to determine the MRSA carriage rate in children in eastern Uganda, and to investigate coexistence between CA-MRSA and hospital-associated (HA-MRSA).<br/><br/>Methods: Between February and October 2011, nasopharyngeal samples (one per child) from 742 healthy children under 5 years in rural eastern Uganda were processed for isolation of MRSA, which was identified based on inhibition zone diameter of ≤19 mm on 30 μg cefoxitin disk. SCCmec and spa typing were performed for MRSA isolates.<br/><br/>Results: A total of 140 S. aureus isolates (18.9%, 140/742) were recovered from the children of which 5.7% (42/742) were MRSA. Almost all (95.2%, 40/42) MRSA isolates were multidrug resistant (MDR). The most prevalent SCCmec elements were types IV (40.5%, 17/42) and I (38.1%, 16/42). The overall frequency of SCCmec types IV and V combined, hence CA-MRSA, was 50% (21/42). Likewise, the overall frequency of SCCmec types I, II and III combined, hence HA-MRSA, was 50% (21/42). Spa types t002, t037, t064, t4353 and t12939 were detected and the most frequent were t064 (19%, 8/42) and t037 (12%, 5/42).<br/><br/>Conclusion: The MRSA carriage rate in children in eastern Uganda is high (5.7%) and comparable to estimates for Mulago Hospital in Kampala city. Importantly, HA-MRSA (mainly of spa type t037) and CA-MRSA (mainly of spa type t064) coexist in children in the community in eastern Uganda, and due to high proportion of MDR detected, outpatient treatment of MRSA infection in eastern Uganda might be difficult.<br/> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 23380 |
| 9 (RLIN) | 23721 |
| 9 (RLIN) | 23722 |
| 9 (RLIN) | 23723 |
| 9 (RLIN) | 23377 |
| 9 (RLIN) | 23724 |
| 9 (RLIN) | 23725 |
| 9 (RLIN) | 23726 |
| 9 (RLIN) | 23727 |
| 9 (RLIN) | 23728 |
| 9 (RLIN) | 19633 |
| 9 (RLIN) | 23376 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1186/s13756-019-0551-1">https://doi.org/10.1186/s13756-019-0551-1</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | ddc |
| Koha item type | RESEARCH ARTICLES |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | 08/26/2021 | RA0226 | 08/26/2021 | 08/26/2021 | RESEARCH ARTICLES |