Multicentre evaluation of significant bacteriuria among pregnant women in the cascade of referral healthcare system in North-western Tanzania: Bacterial pathogens, antimicrobial resistance profiles and predictors (Record no. 19022)
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| 000 -LEADER | |
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| fixed length control field | 02861nam a22002417a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210826b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | J.Seni |
| 9 (RLIN) | 23416 |
| 245 ## - TITLE STATEMENT | |
| Title | Multicentre evaluation of significant bacteriuria among pregnant women in the cascade of referral healthcare system in North-western Tanzania: Bacterial pathogens, antimicrobial resistance profiles and predictors |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mwanza, Tanzania |
| Name of publisher, distributor, etc. | Catholic University of Health and Allied Sciences CUHAS - Bugando |
| Date of publication, distribution, etc. | June 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | Pages 173-179 |
| 490 ## - SERIES STATEMENT | |
| Materials specified | Journal of Global Antimicrobial Resistance Volume 17 |
| Series statement | Journal of Global Antimicrobial Resistance Volume 17 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Abstract<br/><br/>Objectives<br/><br/>The aim of this multicentre study was to evaluate the magnitude of significant bacteriuria (SB) as well as the implicated bacterial pathogens, antimicrobial resistance (AMR) profiles and risk factors for SB among pregnant women attending different levels of healthcare facilities (HCFs) in Tanzania in order to guide antimicrobial therapy and preventive measures.<br/><br/>Methods<br/><br/>Information on sociodemographic and clinical characteristics, midstream urine culture and antimicrobial susceptibility testing was collected from 1828 pregnant women between March 2016 and May 2017. Data were analysed using STATA v.13.0 software.<br/><br/>Results<br/><br/>The prevalence of SB among pregnant women was 17.7% (323/1828; 95% CI 16.0–19.5%), with a predominance of Escherichia coli (164/323; 50.8%), Klebsiella spp. (55/323; 17.0%) and Staphylococcus aureus (28/323; 8.7%). Moreover, 37.5% (121/323) of bacteria were multidrug-resistant [84.3% (102/121) Gram-negative bacteria and 15.7% (19/121) in Gram-positive bacteria; P < 0.001]. Third-generation cephalosporin resistance in E. coli, Klebsiella spp. and other Enterobacteriaceae was 13.4%, 21.8% and 27.5%, respectively, and was higher in strains from a tertiary hospital (OR = 3.27, 95% CI 1.02–10.49; P = 0.046) compared with lower HCFs. Predictors of SB among pregnant women were lack of formal occupation, current hospital admission and presence of co-morbidities.<br/><br/>Conclusions<br/><br/>The prevalence of SB among pregnant women in this study was high (17.7%) and was within the same range reported 10 years ago in a single-centre baseline study. However, there is an increase in AMR in the cascade of referral healthcare system, underscoring the need for health facility level-specific antimicrobial stewardship.<br/><br/>Keywords<br/><br/>Significant bacteriuria; Pregnant women; Referral healthcare system; Tanzania |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 23708 |
| 9 (RLIN) | 23709 |
| 9 (RLIN) | 23710 |
| 9 (RLIN) | 23711 |
| 9 (RLIN) | 23712 |
| 9 (RLIN) | 23422 |
| 9 (RLIN) | 23344 |
| 9 (RLIN) | 23421 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Materials specified | https://doi.org/10.1016/j.jgar.2018.12.024 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | ddc |
| Koha item type | RESEARCH ARTICLES |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Barcode | Date last seen | Price effective from | Koha item type |
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| MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | 08/26/2021 | RA0223 | 08/26/2021 | 08/26/2021 | RESEARCH ARTICLES |