Serological evidence of acute rubella infection among under-fives in Mwanza (Record no. 18970)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02986nam a22002297a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210825b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mariam M. Mirambo |
| 9 (RLIN) | 22927 |
| 222 ## - KEY TITLE | |
| Key title | Rubella; IgM; Under-fives; Mwanza; Tanzania; Congenital rubella syndrome |
| 245 ## - TITLE STATEMENT | |
| Title | Serological evidence of acute rubella infection among under-fives in Mwanza |
| Remainder of title | a threat to increasing rates of congenital rubella syndrome in Tanzania |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mwanza, Tanzania |
| Name of publisher, distributor, etc. | Catholic University of Health and Allied Sciences CUHAS - Bugando & |
| -- | BioMed Central |
| Date of publication, distribution, etc. | 25 May 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | Pages 1-5 |
| 490 ## - SERIES STATEMENT | |
| Materials specified | Italian Journal of Pediatrics volume 42, Article number: 54 (2016) |
| Series statement | Italian Journal of Pediatrics volume 42, Article number: 54 (2016) |
| Volume/sequential designation | Italian Journal of Pediatrics Volume 42 Issue 1 |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Abstract<br/><br/>Background: Control of rubella infection is essential for preventing congenital rubella syndrome (CRS) and one of the important steps is to define a target population for vaccination. Therefore this study was done to determine serological evidence of acute rubella infection among under-fives in order to anticipate the magnitude of rubella virus transmission in Tanzania.<br/><br/>Methods: A cross-sectional study involving children aged between 1 and 59 months was conducted between September and October 2014 before national rubella vaccination campaigns commenced. Rubella IgM antibodies were detected using commercial indirect enzyme-linked immunosorbent assay (ELISA). Data were analyzed using STATA version 11.<br/><br/>Results: A total of230 under-fives were enrolled, their median age was 14 (Interquartile range (IQR) 7–26) months. The overall seroprevalence of rubella IgM antibodies was 10.9 % (25/230) with two confirmed cases of CRS. Two-sample Wilcoxon rank-sum test showed that the median age of rubella IgM seropositive children was significantly higher than that of IgM seronegative children (39 IQR: 18-51months vs. 14 IQR: 7–24 months, P < 0.001). On multivariate logistic regression analysis increase in age (OR: 1.07, 95 % CI; 1.03–1.1, P < 0.001) and residing in rural areas (OR: 8.07, 95 % CI; 1.43–45.6, P = 0.018) were independently found to predict acute rubella infection among under-fives.<br/><br/>Conclusion: Our findings indicate that rubella virus is prevalent in our setting posing a risk of transmitting to childbearing aged women hence increasing the risk of CRS. Increasing prevalence of acute infection with age in under-fives indicates the protective role of maternal antibodies among infants. The sustained vaccination programme of under-fives as effective measure to control CRS should be emphasized in developing countries.<br/><br/> |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 23519 |
| 9 (RLIN) | 19663 |
| 9 (RLIN) | 23365 |
| 9 (RLIN) | 22970 |
| 9 (RLIN) | 23520 |
| 9 (RLIN) | 15820 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="https://doi.org/10.1186/s13052-016-0264-5">https://doi.org/10.1186/s13052-016-0264-5</a> |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | ddc |
| Koha item type | RESEARCH ARTICLES |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | 08/25/2021 | RA0171 | 08/25/2021 | 08/25/2021 | RESEARCH ARTICLES |