Prevalence and Predictors of Renal Dysfunction among HIV Infected Patients Starting Anti-Retroviral Therapy at the Bugando Medical Centre in Mwanza, Tanzania (Record no. 18709)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03096nam a22002297a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20240305193657.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 230214b |||||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | DLC |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | English |
| Language code of text/sound track or separate title | Kiswahili |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Leonard Msango |
| 9 (RLIN) | 22571 |
| 245 ## - TITLE STATEMENT | |
| Title | Prevalence and Predictors of Renal Dysfunction among HIV Infected Patients Starting Anti-Retroviral Therapy at the Bugando Medical Centre in Mwanza, Tanzania |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mwanza, Tanzania: |
| Name of publisher, distributor, etc. | St. Augustine University of Tanzania |
| Date of publication, distribution, etc. | c2010 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 82 Pages |
| Extent | Includes Refernces and Appendices |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Abstract: <br/><br/>Background: In Tanzania little is published on renal dysfunction amongst HIV infected individuals and no study has yet identified its prevalence or associated clinical and epidemiological factors.<br/><br/>Objectives: To determine the prevalence and predictors for dysfunction among HIV infected patients who were starting ART at the Bugando Care and Treatment Centre.<br/><br/>Materials and Methods: A cross-sectional study was conducted among HIV-infected patients at Bugando Care and Treatment Centre between November 2009 and June 2010. Adult’s patients undergoing counseling for initiation of ART were enrolled. Patients with diabetes mellitus, hypertension, febrile illness, HBV/HCV infection, or renal diseases not associated with HIV (SCD, UTI, pregnancy) were excluded. Patients were interviewed using standard questionnaires and physical examination was performed. Spot urine dipstick for proteinuria and micro albuminuria, CD4 count, serum creatinine, and renal ultrasound were performed to all patients. Both Cockcroft Gault and MDRD equations were used to estimate GFR.<br/><br/>Results: A total of 355 HIV patients were enrolled into this study. The mean age was 36. 1±7 years, of which 65% were females. Most patients (69%) were in HIV stage II disease. Most patients, 87% had CD4+T lymphocytes count less than 200cells/µl. About 13% had abnormal echogenic kidneys and 2.8% had enlarged echogenic kidneys on ultrasound, overall, 88.7% of patients had evidence of renal dysfunction (eGFR < 90mil/min/1.7m2 or micro albuminuria, but heavy proteinuria was rare. The prevalence of HIVAN was 11.8%. Lower rates of moderate to severe renal insufficiency were identified by the MDRD equation (33% vs. 17%) respectively, (p <10.001). On univariate analysis followed multivariate analysis female gender (OR 3.0, p<0.001, 95% CI 1.8-5.1), symptomatic HIV infection (OR 1.6, p<0.01, 95% CI 1.2-2.3), CD4 counts less than 200cell/µl (OR 2.2, p<0.04, 95% CI 1.1-4.8) and BMI<18.5 (OR 0.4, p<0.001, 95% CI 0.2-0.8, were independent predictors of severe renal dysfunction (eGFR<60mil/min/1.73m2).<br/><br/>Conclusions and Recommendations: The high prevalence of renal dysfunction among HIV-infected patients in our cohort underscores the need for routine, resource appropriate screening algorithms for renal dysfunction, and prior to the initiation of ART. <br/> |
| 600 ## - SUBJECT ADDED ENTRY--PERSONAL NAME | |
| General subdivision | Internal Medicine |
| 9 (RLIN) | 15587 |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 22760 |
| 9 (RLIN) | 22817 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | ddc |
| Koha item type | POSTGRADUATE DISSERTATIONS |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | 02/14/2023 | CREC/462023 | 02/14/2023 | 02/14/2023 | POSTGRADUATE DISSERTATIONS |