Prevalence and Predictors of Extended Spectrum Betalactamases Producing Enterobactericeae Neonatal Sepsis at the Bugando Medical Centre Mwanza, Tanzania (Record no. 18673)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 04038nam a22002897a 4500 |
| 001 - CONTROL NUMBER | |
| control field | CUHAS/MMED/6000140/T/14 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | CUHAS/MMED/6000140/T/14 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20240417122333.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 230130b |||||||| |||| 00| 0 eng d |
| 028 ## - PUBLISHER OR DISTRIBUTOR NUMBER | |
| Source | Phone: +255 28 298 3384 |
| Source | Fax: +255 28 298 3386 |
| Source | Email: vc@bugando.ac.tz |
| Source | Website: www.bugando.ac.tz |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | CUHAS/MMED/6000140/T/14 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | ddc |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | English |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Rehema Irene Marando |
| 9 (RLIN) | 48303 |
| Dates associated with a name | [Female] |
| Relator term | CUHAS/MMED/6000140/T/14 |
| 245 ## - TITLE STATEMENT | |
| Title | Prevalence and Predictors of Extended Spectrum Betalactamases Producing Enterobactericeae Neonatal Sepsis at the Bugando Medical Centre Mwanza, Tanzania |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mwanza, Tanzania: |
| Name of publisher, distributor, etc. | Catholic University of Health and Allied Sciences [CUHAS – Bugando] : |
| Date of publication, distribution, etc. | c2017 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 66 Pages |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | ABSTRACT<br/><br/>Background: Neonatal sepsis is a worldwide problem and accounts for 2 million deaths of the newborns every year. In the developing countries, neonatal sepsis accounts for 30-50% of the neonatal deaths. Neonatal sepsis due to extended-spectrum-beta lactamases producing enterobactericeae (ESBL-PE) is on the increase and has been found to be associated with significant morbidity and mortality. Here we report the magnitude of ESBL neonatal sepsis and factors associated to it.<br/><br/>Methods: This was a hospital based cross-sectional study conducted at the Bugando Medical Centre (BMC) neonatal units between July 2016 and December 2016. Neonates and their mothers/guardians were enrolled and screened for ESBL-PE colonization. In addition, blood culture was done to all neonates. Demographic and clinical data were collected using standard structured data collection tool. The isolates were confirmed to be ESBL-PE by disk approximation method. Step wise logistic regression analysis was done to determine predictors for ESBL-PE neonatal sepsis, ESBL-PE colonization and mortality using STATA-11 software.<br/><br/>Results: A total of 304 neonates with median age of 6 days (IQR 3-9) were enrolled between July 2016 and December 2016. Out of 304 neonates, 166(54.6%; 95%CI: 49-60.1) were found to be colonized by ESBL-PE. Neonatal ESBL-PE sepsis was detected in 32 (10.5%, 95%CI: 7.1- 13.9) of neonates. Factors found to predict neonatal ESBL-PE sepsis were; admission at neonatal Intensive Care Unit (NICU) (OR: 3.02, 95%CI; 1.19-7.69, P=0.021), positive mother ESBL-PE colonization (OR: 2.8, 95% CI; 1.29-6.3, P=0.009) and positive neonate ESBL-PE colonization (OR: 3.1, 95% CI; 1.19-7.99, P=0.021). Positive ESBL-PE colonization of the mother (OR: 2.19, 95%CI 1.3-3.8, P=0.005) and history of neonatal antibiotic use (OR:1.73, 95%CI 1-2.9, P=0.048) were found to predict neonatal ESBL-PE colonization. Deaths occurred in 55(18.1%, 95% CI 13.4-22.4) of the neonates. Predictors of death were being admitted at NICU (OR 2.7, 95%CI 1.2-6, p=0.015), referral from other centres (OR 2.9, 95%CI 1.4-6.1, P=0.004) and positive ESBL-PE neonatal sepsis (OR 3.2, 95%CI 1.3-7.7, p=0.011). Out of 60 laboratory confirmed neonatal sepsis, 45(75%) were due to gram negative enteric bacteria of which 32/45(71%) were due ESBL-PE. Klebsiella pneumoniae isolates were predominantly found to infect and colonize neonates.<br/><br/>Conclusion: Majority of the neonates at BMC neonatal units were infected with ESBL producing Klebsiella pneumoniae. Maternal and neonatal ESBL-PE colonization and being admitted at NICU were important risk factors for ESBL-PE neonatal sepsis. Neonates referred from other centres, infected with ESBL-PE and admitted at NICU had significantly high mortality rate. There is a need to do blood culture to every child with signs and symptoms of sepsis for early detection of ESBL-PE sepsis and early intervention to reduce its prevalence and hence mortality.<br/> |
| 600 ## - SUBJECT ADDED ENTRY--PERSONAL NAME | |
| General subdivision | Paediatrics and Child Health |
| 9 (RLIN) | 33433 |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 19597 |
| 9 (RLIN) | 22515 |
| 9 (RLIN) | 22966 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | ddc |
| Koha item type | POSTGRADUATE DISSERTATIONS |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Barcode | Date last seen | Copy number | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | 01/30/2023 | CREC/072023 | 01/30/2023 | CREC/072023 | 01/30/2023 | POSTGRADUATE DISSERTATIONS |