Incidence and Associated Factors of Immunological Non Response Among Adult HIV Patients Receiving First Line Cart at Bugando HIV Care and Treatment Services in Mwanza Tanzania; A Retrospective- Follow Up Study (Record no. 18672)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03683nam a22003017a 4500 |
| 001 - CONTROL NUMBER | |
| control field | CUHAS/MMED/6000221/T/16 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | CUHAS/MMED/6000221/T/16 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20240418143647.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 230130b |||||||| |||| 00| 0 eng d |
| 028 ## - PUBLISHER OR DISTRIBUTOR NUMBER | |
| Source | Phone: +255 28 298 3384 |
| Source | Fax: +255 28 298 3386 |
| Source | Email: vc@bugando.ac.tz |
| Source | Website: www.bugando.ac.tz |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | CUHAS/MMED/6000221/T/16 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | ddc |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | English |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Adroster Method Kyakabanja |
| Dates associated with a name | [Male] |
| 9 (RLIN) | 48297 |
| Relator term | CUHAS/MMED/6000221/T/16 |
| 245 ## - TITLE STATEMENT | |
| Title | Incidence and Associated Factors of Immunological Non Response Among Adult HIV Patients Receiving First Line Cart at Bugando HIV Care and Treatment Services in Mwanza Tanzania; A Retrospective- Follow Up Study |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mwanza, Tanzania: |
| Name of publisher, distributor, etc. | Catholic University of Health and Allied Sciences [CUHAS – Bugando] : |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 75 Pages |
| Extent | Includes Index |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Abstract: <br/><br/>Back ground: The impact of ART is measured by CD4 rise and HVL suppression through regular CD4 and viral load monitoring. There are groups of patients where viral replication is suppressed appropriately with immunologic recovery (concordant immunological responders). Conversely, there are patients with no immunologic recovery but with sustained viral load suppression (discordant immunological non responders (INR)). This type of discordance is associated with poor clinical outcomes and is unstable group. The purpose of this study was to determine the cumulative incidence and associated factors for immunological non responders among adults HIV infected patients on first line cART.<br/><br/>Methods: This was a retrospective follow up study which involved all HIV infected patients who were initiated on cART between January 2016 to June 2018 at Bugando Medical Center CTC Mwanza using first line cART for at least 6months. Face to face interview were conducted by using pre tested structured questionnaire to obtain social demographic informations and adherence by using Morisky adherence score. Blood sample for viral hepatitis B and C, HVL and CD4 cell count were drawn from the patient with no recent results, and were sent to BMC laboratory for processing. Patient’s record was used to retrieve complementary information on baseline investigations at different period of time. Then data were entered to excel spread sheet and analyzed by STATA version 13 to obtain cumulative incidence of immunological non responders and its associated factors, an outcome of interest.<br/><br/>Results: A total of 380 participants were enrolled in study of which, 101(26.58%) of clients full filled criteria for immunological non response (INR) at any time of interest. The cumulative incidence at 6 months, 12 months and 24 months were 27 (7.11%), 41 (23.30%) and 57 (42.22%) respectively. The odds of becoming INR were dependently associated with baseline CD4 count >200cells/µl (OR 3.2, p=<0.001), age >60years (OR=3.5, P=0.006), and being on ART treatment longer >12months (OR 3.5, P=<0.001).<br/><br/>Conclusion: The cumulative incidence of INR in this study is relatively higher compared to other studies in East Africa. The baseline CD4 count >200cell/µl, age >60years, and being on cART more than 12months were dependently associated factors. Predictors of INR from this study can potentially be useful in identification of patients at high risk of being INR when categorizing patients for HIV differentiated care. <br/> |
| 600 ## - SUBJECT ADDED ENTRY--PERSONAL NAME | |
| General subdivision | Internal Medicine |
| 9 (RLIN) | 15587 |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 22747 |
| 9 (RLIN) | 19701 |
| 9 (RLIN) | 22748 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | ddc |
| Koha item type | POSTGRADUATE DISSERTATIONS |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Barcode | Date last seen | Copy number | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | 01/30/2023 | CREC/062023 | 01/30/2023 | CREC/062023 | 01/30/2023 | POSTGRADUATE DISSERTATIONS |