Molecular identification of Schistosoma haematobium and Schistosoma bovis hybrid species isolated from primary school children and their susceptibility to Praziquantel treatment in Shinyanga District, North-west Tanzania (Record no. 18565)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03728nam a22003257a 4500 |
| 001 - CONTROL NUMBER | |
| control field | CUHAS/MPH/6000250/T/20 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | CUHAS/MPH/6000250/T/20 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20240423161955.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 221208b |||||||| |||| 00| 0 eng d |
| 028 ## - PUBLISHER OR DISTRIBUTOR NUMBER | |
| Source | Wurzburg Road 35, BMC Premises, Post Code: 33102: |
| Source | P. O Box 1464, Mwanza – Tanzania: |
| Source | Phone: +255 28 298 3384: |
| Source | Fax: +255 28 298 3386 |
| Source | Email: vc@bugando.ac.tz |
| Source | Website: www.bugando.ac.tz |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | CUHAS/MPH/6000250/T/20 |
| 040 ## - CATALOGING SOURCE | |
| Language of cataloging | English |
| Transcribing agency | ddc |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | English |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Sylivester Yasinta D |
| Dates associated with a name | [Female] |
| 9 (RLIN) | 47105 |
| Relator term | CUHAS/MPH/6000250/T/20 |
| 222 ## - KEY TITLE | |
| Key title | Keywords: |
| Qualifying information | Efficacy, hybridization, Introgression background, Schistosomiasis, S. bovis, S. haematobium, praziquantel, Tanzania. |
| 245 ## - TITLE STATEMENT | |
| Title | Molecular identification of Schistosoma haematobium and Schistosoma bovis hybrid species isolated from primary school children and their susceptibility to Praziquantel treatment in Shinyanga District, North-west Tanzania |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mwanza, Tanzania: |
| Name of publisher, distributor, etc. | Catholic University of Health and Allied Sciences [CUHAS – Bugando] : |
| Date of publication, distribution, etc. | 2022 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | xv: 97 Pages |
| Extent | Includes References and Appendices |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Abstract: <br/><br/>Background: Schistosomiasis is a water-borne parasitic disease with the highest socioeconomic impact after Malaria. Preventive chemotherapy using praziquantel has been used as the main intervention in endemic countries, including Tanzania. Recently, studies in West Africa reported that the occurrence of schistostosoma hybrid species among human of up to 36% is one of the factors suspected affected the efficacy of treatment. This study assessed the occurrence of Schistosoma haematobium x Schistosoma bovis hybrids and their effect on praziquantel treatment outcomes in Shinyanga and Misungwi districts, Northwestern Tanzania.<br/><br/>Methods: A population-based cross-sectional study was conducted. Urine samples were examined for S. haematobium using the urine filtration method. The occurrence of bovis x S. haematobium hybrids in the studied population was determined using Rapid Diagnostic Multiplex PCR.<br/><br/>Results: Out of 1.190 individuals examined, 123 (6.4%) were infected with schistosomma haematobium the prevalence decreased to 6 (0.3%) after the treatment. Males were significantly more infected with urogenital schistosomiasis than females (P <0.001). The prevalence of S. haematobium was significantly higher in school-aged children 7-14 years, however, the association was non-significant on multivariate logistic regression analysis (OR = 1.8, p = 0.218). 0f 115 successful amplified genes for cox 1 mitochondria DNA, the occurrence of Schistosoma haematobium x Schistosoma bovis hybrids infection was 4 (3.5%) varied significantly among villages (P=.035). Praziquantel yielded a satisfactory cure rate above 90% with no significantly differences among age groups, occupations and sexes (P>0.05).<br/><br/>Conclusion: Findings suggest that schistosomiasis is still a public health problem in the study area and S. haematobium x S. bovis hybrid exists. However, the occurrence of S. haematobium x S. bovis hybrid among infected individuals in this study is relatively small which hindered the accurate analysis of praziquantel efficacy against Schistosoma hybrid infection which needs further investigation. Another study with an extended period of assessment and with an increased sample size could improve the evaluation of the efficacy of PZQ on Schistosoma hybrids in the study.<br/> |
| 600 ## - SUBJECT ADDED ENTRY--PERSONAL NAME | |
| General subdivision | Public Health |
| 9 (RLIN) | 30696 |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 45138 |
| 9 (RLIN) | 26705 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | ddc |
| Koha item type | POSTGRADUATE DISSERTATIONS |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Barcode | Date last seen | Copy number | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | 12/08/2022 | CREC/479/2021 | 12/08/2022 | CREC/479/2021 | 12/08/2022 | POSTGRADUATE DISSERTATIONS |