Clinico-Pathological Profile of Urological Malignancies at Bugando Medical Centre, Mwanza Tanzania. (Record no. 18470)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 05290nam a22003377a 4500 |
| 001 - CONTROL NUMBER | |
| control field | CUHAS/MMED/6000229/T/16 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | CUHAS/MMED/6000229/T/16 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20240419115653.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210821b |||||||| |||| 00| 0 eng d |
| 028 ## - PUBLISHER OR DISTRIBUTOR NUMBER | |
| Source | Wurzburg Road 35, BMC Premises, Post Code: 33102: |
| Source | P. O Box 1464, Mwanza – Tanzania: |
| Source | Phone: +255 28 298 3384: |
| Source | Fax: +255 28 298 3386: |
| Source | Email: vc@bugando.ac.tz : |
| Source | www.bugando.ac.tz |
| 035 ## - SYSTEM CONTROL NUMBER | |
| System control number | CUHAS/MMED/6000229/T/16 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | ddc |
| Language of cataloging | English |
| 041 ## - LANGUAGE CODE | |
| Language code of text/sound track or separate title | English |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Joachim Angelo |
| Dates associated with a name | [Male] |
| 9 (RLIN) | 22765 |
| Relator term | CUHAS/MMED/6000229/T/16 |
| 210 ## - ABBREVIATED TITLE | |
| Abbreviated title | ABBREVIATIONS |
| Qualifying information | ADT = Androgen deprivation therapy BMC = Bugando Medical Centre CI = Confidence interval CIS = Carcinoma in situ CT = Computed Tomography CUHAS = Catholic University of Health and Allied Sciences DRE = Digital rectal examination ESR = Erythrocyte Sedimentation Rate FBP = Full Blood Picture IQR = Inter-Quartile Range IVU = Intra-venous urogram KUB = Kidney, Ureter and Bladder LUTS = Lower urinary tract symptoms M.MED = Master of Medicine MRI = Magnetic Resonance Imaging MUHAS = Muhimbili Univrsity of Health and Allied Sciences PSA = Prostate Specific Antigen RCC = Renal Cell Carcinoma SCC = Squamous Cell Carcinoma SD = Standard deviation SOPD = Surgical Outpatient Department SPSS = Statistical package for social sciences TCC = Transitional Cell Carcinoma TNM = Tumor, Nodal and Metastasis TRUS = Trans – rectal ultrasound USS = Ultrasonography WT = Wilm‘s Tumor |
| 222 ## - KEY TITLE | |
| Key title | OPERATIONAL DEFINITIONS |
| Qualifying information | Disease pattern: Was defined as definitive diagnosis of the patient in terms of anatomical location and histopathological results. |
| 245 ## - TITLE STATEMENT | |
| Title | Clinico-Pathological Profile of Urological Malignancies at Bugando Medical Centre, Mwanza Tanzania. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mwanza, Tanzania: |
| Name of publisher, distributor, etc. | Catholic University of Health and Allied Sciences [CUHAS - Bugando] : |
| Date of publication, distribution, etc. | 2019 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | xiii; 71 Pages |
| Extent | Includes References and Appendices |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Abstract:<br/><br/>Background: Urological malignancies global incidence has been increasing at an alarming rate despite improved primary prevention, detection and treatment. In Tanzania, they contribute a major burden in cancer morbidities and mortalities. At Bugando Medical Centre (BMC), urological malignancies are a single most common cause of urological and oncological admissions. The aim of this study was to determine the clinico–pathological profile of urological malignancies at BMC. <br/><br/>Methods: This was a hospital–based, prospective and retrospective descriptive study involving patients with histopathologically confirmed urological malignancies at BMC. The retrospective part was for 3 years taking patients from March 2016 to February 2019 whereas the prospective part was for 3 months enrolling patients from March 2019 to May 2019. In each patient data including; demographic profile, clinical presentation, anatomical site and histopathology results were collected and analyzed using STATA.<br/><br/>Results: A total of 662 patients (M: F ratio = 3.8:1) were studied. The median age at presentation was 67 (IQR, 54 to 76 years), the duration of symptoms ranged from 2 months to 4 years with a median duration of 12 months. The commonest clinical presentations were lower urinary tract symptoms (LUTS) 71.1% (470/662), hematuria 33.8% (224/662), bone pain 31.0% (205/662), abdominal pain (loin/suprapubic) 28.7% (190/662), abdominal mass (loin/suprapubic) 19.3% (128/662) and weight loss 12.4% (82/662). The majority of patients presented late with an advanced stage of cancer. Prostate was the commonest anatomical site affected 58.0% (384/662) followed by the urinary bladder 28.1% (186/662). Bladder cancer was the commonest among females 78.1% (107/137) followed by the kidney 21.2% (29/137) and the female gender was commonly affected for the bladder and kidney cancers (M:F = 1:1.4 and 1:1.3 respectively). Adenocarcinoma was the leading histopathological type for prostate cancer 99.7% (383/384) while squamous cell carcinoma (SCC) was the commonest histopathology for bladder cancer 62.4% (116/186). The leading kidney histology was nephroblastoma (Wilm‘s tumor) in children 57.7% (30/52) and renal cell carcinoma (RCC) in adults 30.8% (16/52). <br/><br/>Conclusion: The most common clinical presentation of urological malignancies in our patients were found to be lower urinary tract symptoms (LUTS), hematuria, bone pain, abdominal pain (loin/suprapubic), abdominal mass (loin/suprapubic) and weight loss. Furthermore, the majority of patients presented late with an advanced stage of cancer. The most common anatomical site affected was the prostate. Bladder cancer was the commonest among female. Adenocarcinoma was the most frequent histological type for the prostate cancer whereas squamous cell carcinoma was the leading for bladder cancer. The commonest histological type for kidney cancer was nephroblastoma in children and renal cell carcinoma in adults. Resources should be allocated based on the commonest urological malignancies in our setting.<br/> |
| 600 ## - SUBJECT ADDED ENTRY--PERSONAL NAME | |
| General subdivision | Medicine in Urology |
| 9 (RLIN) | 48296 |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 20966 |
| 9 (RLIN) | 19776 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | ddc |
| Koha item type | POSTGRADUATE DISSERTATIONS |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | 08/21/2021 | PD0331 | 08/21/2021 | 08/21/2021 | POSTGRADUATE DISSERTATIONS |