Impact of ART on renal function among HIV infected adults starting ART at Bugando Medical Centre: Years follow up and comparison of eGFR Equations (Record no. 18293)
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| 000 -LEADER | |
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| fixed length control field | 02672nam a22001937a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210820b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Bonaventura, Mpondo. C. T |
| Dates associated with a name | CUHAS/6000048/T/09 |
| 9 (RLIN) | 22572 |
| 245 ## - TITLE STATEMENT | |
| Title | Impact of ART on renal function among HIV infected adults starting ART at Bugando Medical Centre: Years follow up and comparison of eGFR Equations |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mwanza, Tanzania: |
| Name of publisher, distributor, etc. | Catholic University of Health and Allied Sciences CUHAS - Bugando |
| Date of publication, distribution, etc. | c2012 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | x; 56 Pages |
| Extent | Includes References and Appendices |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Abstract: <br/><br/>Background: Prevalence of renal dysfunction has been shown to be very high in HV positive adults initiating ART worldwide. The impact of ART on renal dysfunction is not very clear as some studies document benefit while others show no benefit on renal function.<br/><br/>Objectives: To determine the status of renal function is a cohort of HIV infected adults screened for renal dysfunction at the time of initiating ART and attending Bugando CTC after being on ART for over one year.<br/><br/>Materials and Methods: A retrospective cohort study was performed among HIV-positive adults screened for renal dysfunction for mid-November 2009 through February 2010. Patients were interviewed through designed questionnaires. Spot urine for proteinuria and microalbuminuria, CD4 cell count and serum creatinine were done to all patients. Both CG and MDRD equations were used to calculate eGFR.<br/><br/>Results: Out of the 355 patients enrolled in the study at the time of ART initiation, 66 did not have baseline information (unknown status), 17 had died, 32 were lost to follow up, 51 were transferred out and 189 were actively following up at the CTC. Prevalence of moderate to severe renal dysfunction was found in 5.3% of the patients at follow up compared to 29% at the time of ART initiation. Median serum creatinine decreased by 18.2umol/l, a decrease of (22.8%) from baseline, while the median eGFR rose from 72.7ml/min/1.73m2 to 103.4ml/min/1.73m2 (an increase of 42%). The improvement was independent of the first line regimen used. Improvement was significantly associated with the baseline renal dysfunction.<br/><br/>Conclusion and Recommendations: Renal dysfunction was common in this cohort of HIV positive adults initiating ART, but significantly improved after a median follow up of 2 years on ART. This underscores the need for early screening and initiation of ART in this population improve their outcome.<br/> |
| 600 ## - SUBJECT ADDED ENTRY--PERSONAL NAME | |
| General subdivision | Internal Medicine |
| 9 (RLIN) | 15587 |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 22760 |
| 9 (RLIN) | 22817 |
| 9 (RLIN) | 23057 |
| 9 (RLIN) | 48385 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | ddc |
| Koha item type | POSTGRADUATE DISSERTATIONS |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Barcode | Date last seen | Price effective from | Koha item type |
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| MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | 08/20/2021 | PD0144 | 08/20/2021 | 08/20/2021 | POSTGRADUATE DISSERTATIONS |