Chronic kidney disease in children with sickle cell disease attending Bugando Medical Centre (Record no. 18251)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03763nam a22001697a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210819b |||||||| |||| 00| 0 eng d |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Kimaro, Donald. Pransisca |
| Dates associated with a name | CUHAS/6000129/T/13 |
| 9 (RLIN) | 22453 |
| 245 ## - TITLE STATEMENT | |
| Title | Chronic kidney disease in children with sickle cell disease attending Bugando Medical Centre |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Mwanza, Tanzania: |
| Name of publisher, distributor, etc. | Catholic University of Health and Allied Sciences CUHAS - Bugando |
| Date of publication, distribution, etc. | 2016 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | xiii; 65 Pages |
| Extent | Includes References and Appendices |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Abstract: <br/><br/>Background: The prevalence of Sickle cell disease (SCD) is high around the Lake Zone in Tanzania. The kidney is one of the affected organs in SCD. Renal damage is preceded by asymptomatic presentations like microalbuminuria (MA) which can be detected early to allow interventions that may slow the disease progression and prevent end stage renal disease (ESRD). Despite high prevalence of SCD in the Lake Zone, there is a scarcity of data on the prevalence and factors associated with chronic kidney disease (CKD) among children with SCD in Mwanza.<br/><br/>Objectives: To determine the prevalence and factors associated with CKD among children with SCD at Bugando Medical Centre.<br/><br/>Material and Methods: This was a hospital based cross-sectional study with a prospective follow up component. A total of 187 children aged 6 months to 12 years with SCD attending the pediatric sickle cell disease clinic at BMC during the study period were enrolled into the study and screened for features suggestive of renal dysfunction. Subjects with renal dysfunction were followed up after 3 months to confirm the presence of CKD. Few confounders of chronic kidney disease like schistosomiasis, HIV infection, and diabetes mellitus were assessed in all participants and Hepatitis B and C infection for those with renal dysfunction. Data analysis was done using STATA version 13.0.<br/><br/>Results: A total of 187 children were enrolled. Fifty seven (30.5%) met the criteria of renal dysfunction a baseline, of which 53 (28.4%) had positive albuminuria and 5 (2.7%) had eGFR <60mls/ ml/min/1.73 m². Out of those with renal of dysfunction, 53 were available for follow up at the end of three months. Thirty five (18.7%) had CKD, of which 34 (18.2%) had albuminuria and 3 (1.6%) had an eGFR< 60ml/min/1.73m² at 3 months follow up. Factors associated with chronic kidney disease positive history of acute chest syndrome (p=0.003), lower hemoglobin level (p=0.009), positive urine schistosoma Circulating Cathodic Antigen (CCA) test (p<0.001), moderate to severe malnutrition (p=0.001) and hematuria (p=0.002). There were five children with history of kidney disease and all of them had CKD.<br/><br/>Conclusion and Recommendation: High prevalence of CKD was observed among children with SCD attending clinic in Mwanza, Screening for renal disease should be performed on all children with SCD on a regular basis, particularly in those with a positive history of acute chest syndrome, lower hemoglobin level, moderate to severe malnutrition, history of neurological deficit and family history of kidney disease. Screening and treatment of urine schistosomiasis is of utmost value as schistosomiasis contributes to a burden of renal disease in children with SCD in Mwanza. Screening for micro albuminuria is a reasonable measure even when serum creatinine is not feasible.<br/><br/> |
| 600 ## - SUBJECT ADDED ENTRY--PERSONAL NAME | |
| General subdivision | Pediatrics and Child Health |
| 9 (RLIN) | 48299 |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 22934 |
| 9 (RLIN) | 48374 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | ddc |
| Koha item type | POSTGRADUATE DISSERTATIONS |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | 08/19/2021 | PD0027 | 08/19/2021 | 08/19/2021 | POSTGRADUATE DISSERTATIONS |