Aplastic Anemia and Other Bone Marrow Failure Syndromes (Record no. 17892)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02700nam a22003257a 4500 |
| 001 - CONTROL NUMBER | |
| control field | A. 8359 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20240305193421.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 220510b |||||||| |||| 00| 0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 0387970304 |
| International Standard Book Number | 9780387970301 |
| 040 ## - CATALOGING SOURCE | |
| Transcribing agency | DLC |
| 082 ## - DEWEY DECIMAL CLASSIFICATION NUMBER | |
| Classification number | 616.152 SHA |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Nasrollah T. Shahidi |
| 9 (RLIN) | 37193 |
| 245 ## - TITLE STATEMENT | |
| Title | Aplastic Anemia and Other Bone Marrow Failure Syndromes |
| 250 ## - EDITION STATEMENT | |
| Edition statement | illustrated |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | London |
| Name of publisher, distributor, etc. | Springer New York, 1990 Original from the University of Michigan Digitized |
| Date of publication, distribution, etc. | 7 Aug 2008 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 236 pages |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | During the past decade, there have been numerous direct and indirect scientific contributions to both the etiology and therapy of aplastic anemia and related bone marrow failure syndromes. Clinical observations, such as autologous bone marrow recovery after conditioning with immunosup pressive agents for bone marrow transplantation; failure to achieve en graftment in some identical twins without prior immunosuppressive ther apy; and hematologic response to immunosuppressive agents, have led to the concept of immune-mediated etiology of acquired aplastic anemia. Such a concept was further strengthened by laboratory findings, implicat ing the role of activated cytotoxic T lymphocytes and abnormal produc tion of inhibitory lymphokines. The immunologic mechanisms may also apply to the idiosyncratic bone marrow aplasias associated with drugs, toxic chemicals, and viruses. These agents may alter normal cellular recog nition sites by interacting with cellular components and result in loss of self tolerance. Immunologic mechanisms have long been advocated in many other organ failures, and the hemopoietic organ is no exception. It is of interest that parallel clinical and laboratory investigations in juvenile diabetes mellitus type I and in rodent models of this disease have yielded results compatible with the same pathogenic mechanisms. The infiltration of pancreatic islets by activated T lymphocytes, functional and morphological alterations of islet cells upon incubation with lymphokines such as gamma interferon and tumor necrosis factor, and clinical response to cyclosporine are a few examples. |
| 600 ## - SUBJECT ADDED ENTRY--PERSONAL NAME | |
| General subdivision | Science / Life Sciences / Molecular Biology |
| 9 (RLIN) | 27008 |
| General subdivision | Science / Life Sciences / Cell Biology |
| 9 (RLIN) | 27913 |
| General subdivision | Medical / Pediatrics |
| 9 (RLIN) | 26838 |
| General subdivision | Medical / Oncology / General |
| 9 (RLIN) | 26891 |
| General subdivision | Medical / Oncology |
| 9 (RLIN) | 29196 |
| General subdivision | Medical / Immunology |
| 9 (RLIN) | 26958 |
| General subdivision | Medical / Hematology |
| 9 (RLIN) | 27137 |
| General subdivision | Medical / Clinical Medicine |
| 9 (RLIN) | 26816 |
| General subdivision | Medical › Oncology › General |
| 9 (RLIN) | 26780 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | ddc |
| Koha item type | BOOKS |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | 05/10/2022 | 616.152 SHA | A. 8359 | 05/10/2022 | 05/10/2022 | BOOKS |