Informing Clinical Practice in Nephrology (Record no. 13871)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 03213nam a22001937a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 210521b |||||||| |||| 00| 0 eng d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER | |
| International Standard Book Number | 9783319102917 |
| International Standard Book Number | 9783319102924 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Mohsen El Kossi |
| 9 (RLIN) | 10811 |
| 245 ## - TITLE STATEMENT | |
| Title | Informing Clinical Practice in Nephrology |
| Remainder of title | The Role of RCTs |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | London. New York |
| Name of publisher, distributor, etc. | Springer International Publishing Switzerland |
| Date of publication, distribution, etc. | 2015 |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 246 Pages |
| 500 ## - GENERAL NOTE | |
| General note | Includes References |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Nephrology practice has been informed over the last quarter of a century by a large number of<br/>clinical trials that translated animal experimentation findings into the bedside. These clinical<br/>trials have also informed and shaped the Nephrology Practice Guidelines worldwide.<br/>However, a closer look at many of these clinical trials finds them wanting and reveals major<br/>flaws that make their conclusions challengeable and their subsequent impact of practice misguided. Consequently, our practice and guidelines have been shaped in some instances by<br/>clinical trials that are inconclusive at best and misleading in their conclusions and recommendations at worst.<br/>This has prompted the editors of this monograph along with its publisher to call upon<br/>experts in the various fields of nephrology to undertake a thorough and critical appraisal and<br/>evaluation of the published clinical trials that have shaped our practice in recent times in general nephrology, dialysis, and transplantation. We have also included a critical appraisal template based on standard guidelines including the CONSORT statement to allow for a<br/>comparative evaluation of clinical trials within one area of nephrology and also across its different fields: General Nephrology, Dialysis, and Transplantation. Of note, the implementation<br/>of the Critical Appraisal template was left entirely to individual authors’ evaluations.<br/>Parameters Yes No Comment<br/>Validity<br/>Is the Randomization Procedure well described? +1 −1<br/>Double blinded? +2 −2<br/>Is the sample size calculation described/adequate? +3 −3<br/>Does it have a hard primary endpoint? +1 −1<br/>Is the endpoint surrogate? −2 0<br/>Is the follow-up appropriate? +1 −1<br/>Was there a Bias? −2 +2<br/>Is the drop out >25 %? −1 +1<br/>Is the analysis ITT? +3 −3<br/>Utility/Usefulness<br/>Can the findings be generalized? +1 −1<br/>Was the NNT <100? +1 −1<br/>Score …<br/>The critical appraisals of mostly randomized clinical trials (RCT) have revealed the strength<br/>but also the weakness of the published literature upon which we base our current practice.<br/>We hope that the monograph will alert nephrologists worldwide to the value of published<br/>RCT and provide them with a most valuable reference that assists them in their understanding<br/>and evaluation of key publications in nephrology. This in turn should allow them to better<br/>judge the literature upon which they base their daily clinical practice and avoid misplaced and<br/>unfounded assumptions.<br/>The quality of the clinical practice and health care we deliver as nephrologists depend to a<br/>large extent on the quality of the RCT and publications we base our knowledge and guidelines<br/>upon. |
| 654 ## - SUBJECT ADDED ENTRY--FACETED TOPICAL TERMS | |
| General subdivision | Nephrology |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| 9 (RLIN) | 10812 |
| 9 (RLIN) | 10813 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | ddc |
| Koha item type | BOOKS |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Collection | Home library | Current library | Shelving location | Date acquired | Total checkouts | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | MWALIMU NYERERE LEARNING RESOURCES CENTRE-CUHAS BUGANDO | 05/21/2021 | EBS3473 | 05/21/2021 | 05/21/2021 | BOOKS |