Tumors of the Central Nervous System
M.A. Hayat
Tumors of the Central Nervous System - illustrated - London: Springer Science & Business Media, c2012 - 347 pages - Volume 8: Astrocytoma, Medulloblastoma, Retinoblastoma, Chordoma, Craniopharyngioma, Oligodendroglioma, and Ependymoma Volume 8 of Tumors of the Central Nervous System .
With tens of thousands of new CNS tumor cases each year in the US alone, this series of publications is a valuable aid to the diagnosis and treatment of these problematic neoplasms. Now, the eighth in the set returns to the topic of brain tumors, dealing with seven distinct types: astrocytoma, medulloblastoma, retinoblastoma, chordoma, craniopharyngioma, oligodendroglioma, and ependymoma. After updating the classification of medulloblastoma the volume provides an overview of ependymoma as well as describing the delineation of prognosis based on the genetic aberrations of the latter patients. The material offers key insights into the molecular pathways involved in tumor biology, such as the role of E-cadherin gene instability, carbonic anhydrase II, urokinase plasminogen activator, and Wnt signaling in meningioma. Contributors explain the genetic and clinical features associated with recurring meningioma, including the role played by erythropoietin receptor, and examine the way in which OTX2 transcription factor functions as an oncogene in medulloblastoma. With much more besides, including discussion of the molecular mechanisms that result in resistance to chemotherapy in medulloblastoma, this volume and its companions have a positive role to play in inspiring a new generation of researchers to design new drugs that are better targeted—and thus more effective.
9789400742130 9400742134 = Common terms and phrases aberrations activation analysis anaplastic apoptosis astrocytes astrocytoma bevacizumab blastoma bleomycin bone brain tumors c-MET Cancer carbon ion caspase-8 cell cycle cell lines Central Nervous System checkpoint chemotherapy chondrosarcomas chordoma chromosome clinical cranial craniopharyngiomas craniospinal craniotomy diagnosis differentiation disease DNA damage dose DSBs endoscopic ependymal ependymomas epigenetic extraneural factors follow-up genetic genomic gliomas grade hereditary histological induced inhibitor intracranial ependymomas involved irradiation Kassam kinase lesions malignant astrocytomas median medulloblastoma medulloblastoma cell metastatic methylation microRNA miRNA molecular mutations Neurosurg Neurosurgery oligodendroglioma oncogenic optic OTX2 outcome overall survival pathway pediatric phosphorylation prognostic protein proton Radiat Oncol Biol radiation therapy radiotherapy rates receptor recurrent region reported retinoblastoma patients retinoma risk role signaling skull base chordomas spinal Springer Science+Business Media surgery surgical survivin survivors target tion tissue toma toxicity TRAIL transsphenoidal treated treatment tumor cells
--Science / Life Sciences / Neuroscience--Management & Reimbursement -- Medical / Practice --Medical / Pathology--Medical / Oncology / General --Medical / Neuroscience --Medical / General --Medical / Family & General Practice --Medical › Oncology › General
Tumors of the Central Nervous System - illustrated - London: Springer Science & Business Media, c2012 - 347 pages - Volume 8: Astrocytoma, Medulloblastoma, Retinoblastoma, Chordoma, Craniopharyngioma, Oligodendroglioma, and Ependymoma Volume 8 of Tumors of the Central Nervous System .
With tens of thousands of new CNS tumor cases each year in the US alone, this series of publications is a valuable aid to the diagnosis and treatment of these problematic neoplasms. Now, the eighth in the set returns to the topic of brain tumors, dealing with seven distinct types: astrocytoma, medulloblastoma, retinoblastoma, chordoma, craniopharyngioma, oligodendroglioma, and ependymoma. After updating the classification of medulloblastoma the volume provides an overview of ependymoma as well as describing the delineation of prognosis based on the genetic aberrations of the latter patients. The material offers key insights into the molecular pathways involved in tumor biology, such as the role of E-cadherin gene instability, carbonic anhydrase II, urokinase plasminogen activator, and Wnt signaling in meningioma. Contributors explain the genetic and clinical features associated with recurring meningioma, including the role played by erythropoietin receptor, and examine the way in which OTX2 transcription factor functions as an oncogene in medulloblastoma. With much more besides, including discussion of the molecular mechanisms that result in resistance to chemotherapy in medulloblastoma, this volume and its companions have a positive role to play in inspiring a new generation of researchers to design new drugs that are better targeted—and thus more effective.
9789400742130 9400742134 = Common terms and phrases aberrations activation analysis anaplastic apoptosis astrocytes astrocytoma bevacizumab blastoma bleomycin bone brain tumors c-MET Cancer carbon ion caspase-8 cell cycle cell lines Central Nervous System checkpoint chemotherapy chondrosarcomas chordoma chromosome clinical cranial craniopharyngiomas craniospinal craniotomy diagnosis differentiation disease DNA damage dose DSBs endoscopic ependymal ependymomas epigenetic extraneural factors follow-up genetic genomic gliomas grade hereditary histological induced inhibitor intracranial ependymomas involved irradiation Kassam kinase lesions malignant astrocytomas median medulloblastoma medulloblastoma cell metastatic methylation microRNA miRNA molecular mutations Neurosurg Neurosurgery oligodendroglioma oncogenic optic OTX2 outcome overall survival pathway pediatric phosphorylation prognostic protein proton Radiat Oncol Biol radiation therapy radiotherapy rates receptor recurrent region reported retinoblastoma patients retinoma risk role signaling skull base chordomas spinal Springer Science+Business Media surgery surgical survivin survivors target tion tissue toma toxicity TRAIL transsphenoidal treated treatment tumor cells
--Science / Life Sciences / Neuroscience--Management & Reimbursement -- Medical / Practice --Medical / Pathology--Medical / Oncology / General --Medical / Neuroscience --Medical / General --Medical / Family & General Practice --Medical › Oncology › General