Glioma Signaling
Glioma Signaling - Second Edition - Biochemistry Nencki Institute of Experimental Biology Warsaw, Poland | Springer Nature Switzerland AG | 2020 - 311 Pages Includes References and Index - Advances in Experimental Medicine and Biology .
Gliomas, developing in the brain from the transformed glial cells, are a very special kind of tumor, extremely refractory to conventional treatments. Therefore, for the development of new antitumor strategies, a better understanding of molecular mechanisms responsible for their biology, growth and invasion is still needed. This book is a reference on cellular signaling processes regulating gliomas physiology and invasiveness.
The work is focused on the mechanism of nucleotide receptor activation by exogenous nucleotides and formation of complex signaling cascades induced by growth factors, cytokines and cannabinoids. The second edition of the book enriched in new chapters provides a framework explaining how signal transduction elements may modulate numerous genetic and epigenetic alterations, describes the role of local microenvironment in cellular growth, progression and invasion and, in the light of extensive new results, presents perspectives concerning potential targets for gliomas therapy.
978-3-030-30650-2 978-3-030-30651-9 (eBook)
0065-2598 2214-8019 (electronic) = Abbracchio acid actin activation adenosine adenylate cyclase adhesion ADP Akt angiogenesis apoptosis arginine arginine deprivation astrocytes astrocytoma ATP Barańska binding Biol Chem brain tumors Burnstock Ca2+ calcium signaling cancer cells Cancer Res cannabinoid Cell Biol cell death cell invasion cell migration cell proliferation cofilin cytokine cytoskeleton differentiation effects EGFR endocannabinoid enzymes expression extracellular Fig function G GBM gene glioblastoma cells glioblastoma multiforme glioma C6 cells growth factor receptor GTPases H histone https://doi human glioblastoma increased induced inhibition inhibitor integrin interaction ligands malignant gliomas mechanisms mediated microglia modulation molecular motility mRNA myosin neurons Neurosci nucleotide nucleotide receptors overexpression P2X receptors P2Y1 receptor patients Pharmacol phosphorylation PI3K PI3K/Akt plasma membrane promotes protein kinase Purinergic Signal Rac1 rat regulation release response Rho role Sci serum signaling pathways Smad STAT STAT3 stem cells stimulation studies SWI/SNF target temozolomide therapeutic tissue transcription transforming growth tumor cells tyrosine kinase UTP vitro vivo Wang Zhang
--Cancer, Cytology, Medical / General, Medical / Oncology / General, Proteins, Science / Life Sciences / Biochemistry, Science / Life Sciences / Cell Biology, Science / Life Sciences / Molecular Biology, Cancer -- Research, Cell receptors, Cellular signal transduction, Gliomas.