Diabetes Mellitus A risk factor for Alzheimer’s Disease
Diabetes Mellitus A risk factor for Alzheimer’s Disease - Division of Neurofunctional Genomics, Department of Immunobiology and Neuroscience Medical Institute of Bioregulation, Kyushu University Fukuoka, Japan | Springer Nature Singapore Pte Ltd | 2019 - 247 Pages Includes References - Advances in Experimental Medicine and Biology .
This book describes the precise mechanisms by which insulin resistance and diabetes mellitus (DM) act as risk factors for Alzheimer’s disease (AD). It opens by discussing the de novo synthesis of insulin in the brain and its functional significance with regard to glucose metabolism and maintenance of neuronal function in the brain. The epidemiological evidence that DM is a risk factor for the development of dementia, including AD as well as vascular dementia, is then examined. Subsequent chapters explore in depth the mechanisms involved in this relationship, including abnormal protein processing, dysregulated glucose metabolism, impaired insulin signaling, and mitochondrial dysfunction. The molecular interactions between diabetes and AD are fully discussed, highlighting the pathological molecular mechanisms induced by diabetes that promote and accelerate AD pathology. Finally, diagnostic biomarkers and potential therapeutic approaches for AD are considered on the basis of the presented evidence. In providing answers to the critical questions of whether and why DM is a risk factor for AD, this book will hold appeal for a wide interdisciplinary audience.
978-981-13-3540-2 (eBook) 978-981-13-3539-6
0065-2598 2214-8019 (electronic)
--Diseases, Medical / Endocrinology & Metabolism, Medical / General, Medical / Neurology, Medical / Neuroscience, Neurology, Neurosciences, Science / Life Sciences / Neuroscience, Alzheimer's disease -- Risk factors, Diabetes.
616.462 NAK