Prevalence of patient ductus arteriosus and treatment outcome among neonates admitted at Bugando Medical Centre, Mwanza Tanzania
Jenifa L Mcharo CUHAS/MD/4001948/T/17
Prevalence of patient ductus arteriosus and treatment outcome among neonates admitted at Bugando Medical Centre, Mwanza Tanzania - Mwanza, Tanzania: Catholic University of Health and Allied Sciences [CUHAS – Bugando] : ©2022 - 41 Pages Includes References and Appendices
Abstract:
Introduction: Patent Ductus Arteriosus (PDA) is one of the most common congenital heart diseases (CHDs) in infants accounting 5% to 10% of all CHDs, associated with high rate of morbidity and mortality. Despite a wide range of pharmacological management (widely used Indomethacin, ibuprofen and acetaminophen) and surgical interventions which may benefits several infants, there is increasing treatment controversy varying markedly between institutions and health care providers. Therefore, this study aimed at determining the prevalence of PDA and outcome of neonates treated with Acetaminophen in Bugando Medical Centre, Mwanza, Tanzania
Methodology: A hospital based retrospective study was conducted from January to August 2021 in Bugando Medical Centre (BMC). A total of 304 neonatal records were extracted in the study by random sampling. Data collection and entry was done using Eppicollect5 application where demographic information and relevant clinical data like, mode of delivery, vitals, reason for admission, Echocardiogram (ECHO) findings before and after treatment, duration of hospital stay and outcome were obtained from patient’s file. SPSS Software version 20 was used for data analysis.
Results: A total of 304 neonates’ records were analysed. The median age of enrolled neonates was 1(IQR:1-22) and more than half,169(55.6%) were male. The prevalence of PDA among all admitted neonates was 18(5.9%). The prevalence of PDA among neonates with congenital heart diseases was 18(64.3%). The treatment outcome of neonates with PDA after seven days on acetaminophen, ECHO report revealed 12(66.7%) neonates attained full closure, and 2(11.1%) had small PDA, 3(16.7%) died before evaluation ECHO. However, by using Chi squared test no predictors for PDA closure were found in this study.
Conclusion: PDA is the most common congenital heart defect in our setting, with good response to acetaminophen treatment. This request for prompt evaluation and intervention to all neonates at risk for early detection and treatment. Further retrospective studies with higher sample size are highly recommended in this setting.
Wurzburg Road 35, BMC Premises, Post Code: 33102: P. O. Box 1464, Mwanza – Tanzania: Phone: +255 28 298 3384: Fax: +255 28 298 3386 Email: vc@bugando.ac.tz Website: www.bugando.ac.tz
--Paediatrics and Child Health--Microbiology & Immunology
Prevalence of patient ductus arteriosus and treatment outcome among neonates admitted at Bugando Medical Centre, Mwanza Tanzania - Mwanza, Tanzania: Catholic University of Health and Allied Sciences [CUHAS – Bugando] : ©2022 - 41 Pages Includes References and Appendices
Abstract:
Introduction: Patent Ductus Arteriosus (PDA) is one of the most common congenital heart diseases (CHDs) in infants accounting 5% to 10% of all CHDs, associated with high rate of morbidity and mortality. Despite a wide range of pharmacological management (widely used Indomethacin, ibuprofen and acetaminophen) and surgical interventions which may benefits several infants, there is increasing treatment controversy varying markedly between institutions and health care providers. Therefore, this study aimed at determining the prevalence of PDA and outcome of neonates treated with Acetaminophen in Bugando Medical Centre, Mwanza, Tanzania
Methodology: A hospital based retrospective study was conducted from January to August 2021 in Bugando Medical Centre (BMC). A total of 304 neonatal records were extracted in the study by random sampling. Data collection and entry was done using Eppicollect5 application where demographic information and relevant clinical data like, mode of delivery, vitals, reason for admission, Echocardiogram (ECHO) findings before and after treatment, duration of hospital stay and outcome were obtained from patient’s file. SPSS Software version 20 was used for data analysis.
Results: A total of 304 neonates’ records were analysed. The median age of enrolled neonates was 1(IQR:1-22) and more than half,169(55.6%) were male. The prevalence of PDA among all admitted neonates was 18(5.9%). The prevalence of PDA among neonates with congenital heart diseases was 18(64.3%). The treatment outcome of neonates with PDA after seven days on acetaminophen, ECHO report revealed 12(66.7%) neonates attained full closure, and 2(11.1%) had small PDA, 3(16.7%) died before evaluation ECHO. However, by using Chi squared test no predictors for PDA closure were found in this study.
Conclusion: PDA is the most common congenital heart defect in our setting, with good response to acetaminophen treatment. This request for prompt evaluation and intervention to all neonates at risk for early detection and treatment. Further retrospective studies with higher sample size are highly recommended in this setting.
Wurzburg Road 35, BMC Premises, Post Code: 33102: P. O. Box 1464, Mwanza – Tanzania: Phone: +255 28 298 3384: Fax: +255 28 298 3386 Email: vc@bugando.ac.tz Website: www.bugando.ac.tz
--Paediatrics and Child Health--Microbiology & Immunology