Prevalence of Antibodies Among Women with Bad Obstetrics History in Mwanza - Tanzania.
Mahamudu, Karim. M CUHAS/BM/1000277/T/16
Prevalence of Antibodies Among Women with Bad Obstetrics History in Mwanza - Tanzania. - Mwanza, Tanzania: Catholic University of Health and Allied Sciences [CUHAS - Bugando] Phone: +255 28 298 3384 : Fax: +255 28 298 3386 : Email: vc@bugando.ac.tz : Website: www.bugando.ac.tz ©04.09.2019 - 49 Pages
Abstract:
Background: Rubella virus infection is a major public health concern due to teratogenic effects to the unborn child and other adverse pregnancy outcomes including still birth, spontaneous abortion and preterm birth. Bad obstetric history (BOH) is common in many resource limited countries and Rubella is among one of implicated pathogens. Despite being common in Tanzania its magnitude among women with bad obstetrics history has not been well studied. The study was conducted to determine the Rubella virus seropositivity among women with bad obstetrics history Mwanza, Tanzania.
Methodology: A cross sectional hospital based study involving 180 women with bad obstetrics history was conducted between May and July 2019 in Mwanza region. Data were collected from participants using pre tested structured questionnaires. Blood samples were collected and detection of Rubella IgM and IgG antibodies from sera were done by using indirect Enzyme-linked Immunosorbent Assay (ELISA). Data were analyzed by using STATA version 13 as per study objectives.
Results: The median age of enrolled women was 28(IQR: 24-34) years and mean parity was 2.4 ± 2.04 children. Out of 180 enrolled women tested, only 1(1.2%, 95% CI 1.1-3.5) tested positive for Rubella IgM and IgG antibodies while 174(96.7%, 95% CI 94.1-99.3) tested positive for Rubella Virus IgG antibodies. None of the factors was found to be associated with Rubella IgG and IgM seropositivity among women with bad obstetric outcomes in Mwanza.
Conclusion and Recommendations: Rubella IgG seropositivity is very high while that of Rubella IgM was very low among women with BOH in Mwanza. None of the factors was found to be associated with Rubella IgG and IgM seropositivity among women with BOH in Mwanza. Rubella virus might be one of the contributing factors to BOH in Mwanza.
--Microbiology and Immunology--Obstetrics and Gynecology --Medical Laboratory Sciences
Prevalence of Antibodies Among Women with Bad Obstetrics History in Mwanza - Tanzania. - Mwanza, Tanzania: Catholic University of Health and Allied Sciences [CUHAS - Bugando] Phone: +255 28 298 3384 : Fax: +255 28 298 3386 : Email: vc@bugando.ac.tz : Website: www.bugando.ac.tz ©04.09.2019 - 49 Pages
Abstract:
Background: Rubella virus infection is a major public health concern due to teratogenic effects to the unborn child and other adverse pregnancy outcomes including still birth, spontaneous abortion and preterm birth. Bad obstetric history (BOH) is common in many resource limited countries and Rubella is among one of implicated pathogens. Despite being common in Tanzania its magnitude among women with bad obstetrics history has not been well studied. The study was conducted to determine the Rubella virus seropositivity among women with bad obstetrics history Mwanza, Tanzania.
Methodology: A cross sectional hospital based study involving 180 women with bad obstetrics history was conducted between May and July 2019 in Mwanza region. Data were collected from participants using pre tested structured questionnaires. Blood samples were collected and detection of Rubella IgM and IgG antibodies from sera were done by using indirect Enzyme-linked Immunosorbent Assay (ELISA). Data were analyzed by using STATA version 13 as per study objectives.
Results: The median age of enrolled women was 28(IQR: 24-34) years and mean parity was 2.4 ± 2.04 children. Out of 180 enrolled women tested, only 1(1.2%, 95% CI 1.1-3.5) tested positive for Rubella IgM and IgG antibodies while 174(96.7%, 95% CI 94.1-99.3) tested positive for Rubella Virus IgG antibodies. None of the factors was found to be associated with Rubella IgG and IgM seropositivity among women with bad obstetric outcomes in Mwanza.
Conclusion and Recommendations: Rubella IgG seropositivity is very high while that of Rubella IgM was very low among women with BOH in Mwanza. None of the factors was found to be associated with Rubella IgG and IgM seropositivity among women with BOH in Mwanza. Rubella virus might be one of the contributing factors to BOH in Mwanza.
--Microbiology and Immunology--Obstetrics and Gynecology --Medical Laboratory Sciences