High diversity of Candida glabrata in a tertiary hospital—Mwanza, Tanzania
Martha F Mushi
High diversity of Candida glabrata in a tertiary hospital—Mwanza, Tanzania - Mwanza, Tanzania: Oxford University Press & Catholic University of Health and Allied Sciences [CUHAS – Bugando] 2019/10/1 - Pages 914-917 - Medical Mycology Volume 57 Issue 7 .
Abstract:
Candida glabrata is a genetically diverse human pathogenic yeast, whose subpopulations have been documented to vary geographically. Here, we report MLST genotypes and antifungal drug susceptibility of C. glabrata isolates from Africa. Among 47 mostly urogenital isolates, we found 13 sequence types, amounting to a 27% genetic population difference. More than half of the isolates were of novel sequence types. ST18 was most predominant and had reduced susceptibility to fluconazole. There was clear segregation of STs between urine and vaginal specimen. In Tanzania, the C. glabrata population is genetically diverse, and divergent from those seen in other countries.
Online ISSN 1460-2709 = C. glabrata, Diversity, MLST antifungal agents africa fluconazole genotype ichthyosis, x-linked sequence tagged sites tanzania genitourinary system yeasts genetics urine vagina sodium thiosulfate candida glabrata
Phone: +255 28 298 3384 Fax: +255 28 298 3386 Email: vc@bugando.ac.tz Website: www.bugando.ac.tz
High diversity of Candida glabrata in a tertiary hospital—Mwanza, Tanzania - Mwanza, Tanzania: Oxford University Press & Catholic University of Health and Allied Sciences [CUHAS – Bugando] 2019/10/1 - Pages 914-917 - Medical Mycology Volume 57 Issue 7 .
Abstract:
Candida glabrata is a genetically diverse human pathogenic yeast, whose subpopulations have been documented to vary geographically. Here, we report MLST genotypes and antifungal drug susceptibility of C. glabrata isolates from Africa. Among 47 mostly urogenital isolates, we found 13 sequence types, amounting to a 27% genetic population difference. More than half of the isolates were of novel sequence types. ST18 was most predominant and had reduced susceptibility to fluconazole. There was clear segregation of STs between urine and vaginal specimen. In Tanzania, the C. glabrata population is genetically diverse, and divergent from those seen in other countries.
Online ISSN 1460-2709 = C. glabrata, Diversity, MLST antifungal agents africa fluconazole genotype ichthyosis, x-linked sequence tagged sites tanzania genitourinary system yeasts genetics urine vagina sodium thiosulfate candida glabrata
Phone: +255 28 298 3384 Fax: +255 28 298 3386 Email: vc@bugando.ac.tz Website: www.bugando.ac.tz